Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients

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dc.contributor.author Fonseca, Henrique Andrade R. [UNIFESP]
dc.contributor.author Fonseca, Francisco A. [UNIFESP]
dc.contributor.author Monteiro, Andrea M.
dc.contributor.author Bianco, Henrique T. [UNIFESP]
dc.contributor.author Boschcov, Paulo [UNIFESP]
dc.contributor.author Brandao, Sergio A. [UNIFESP]
dc.contributor.author Juliano, Luiz [UNIFESP]
dc.contributor.author Gidlund, Magnus
dc.contributor.author Izar, Maria C. [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:47Z
dc.date.available 2016-01-24T14:34:47Z
dc.date.issued 2013-12-01
dc.identifier http://dx.doi.org/10.1007/s12013-013-9585-9
dc.identifier.citation Cell Biochemistry and Biophysics. Totowa: Humana Press Inc, v. 67, n. 3, p. 1451-1460, 2013.
dc.identifier.issn 1085-9195
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37034
dc.description.abstract Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the body mass index (BMI) on the inflammatory, vascular, and immune responses in patients with hypertension na < ve of anti-hypertensive treatment. Hypertensive patients (N = 88) were divided into three groups: normal weight (NW), overweight (OW), and obese (OB) subjects. Anti-oxidized LDL autoantibodies (anti-oxLDL Abs), anti-ApoB-D peptide (anti-ApoB-D) Abs, interleukin (IL)-8 and IL-10, flow-mediated dilation (FMD) of the brachial artery, and 24-h ambulatory blood pressure monitoring (ABPM) were assessed. OB patients presented lower levels of anti-oxLDL Abs and IL-10, higher levels of IL-8, and impaired FMD, when compared to NW and OW (P < 0.05), without differences between groups regarding anti-ApoB-D Abs. After adjusting for age, systolic and diastolic blood pressure, anti-oxLDL Abs were inversely correlated with BMI and waist circumference (r = -0.24, P = 0.02 and r = -0.25, P = 0.02, respectively), whereas ApoB-D correlated with 24-h ABPM (r = 0.22, P = 0.05 for systolic, and r = 0.29, P = 0.01 for diastolic blood pressure). Regression analyses showed inverse associations of anti-oxLDL Abs with BMI (beta = -0.05, P = 0.01) and waist circumference (beta = -0.01, P = 0.02); anti-ApoB-D Abs were associated with systolic and diastolic 24-h ABPM (beta = 0.96, P = 0.04; beta = 1.02, P = 0.005, for systolic and diastolic 24-h ABPM, respectively). Among hypertensive patients, obesity modulates the immune and inflammatory milieu, determining an unfavorable balance of cytokines and reduction in titers of anti-oxLDL Abs. Twenty-four hour ABPM is associated with titers of anti-ApoB-D Abs. en
dc.description.sponsorship National Institute of Complex Fluids, São Paulo, SP, Brazil
dc.format.extent 1451-1460
dc.language.iso eng
dc.publisher Humana Press Inc
dc.relation.ispartof Cell Biochemistry and Biophysics
dc.rights Acesso restrito
dc.subject Autoantibodies en
dc.subject Oxidized LDL en
dc.subject Inflammation en
dc.subject Body mass index en
dc.subject Hypertension en
dc.title Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Natl Inst Complex Fluids
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Natl Inst Nanomat Integrated Markers
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04039030 São Paulo, Brazil
dc.description.affiliation Natl Inst Complex Fluids, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Biomed Sci, Dept Immunol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, BR-04039030 São Paulo, Brazil
dc.description.affiliation Natl Inst Nanomat Integrated Markers, Recife, PE, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04039030 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, BR-04039030 São Paulo, Brazil
dc.identifier.doi 10.1007/s12013-013-9585-9
dc.description.source Web of Science
dc.identifier.wos WOS:000327455400071



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