Increase of angiotensin-converting enzyme activity and peripheral sympathetic dysfunction could contribute to hypertension development in streptozotocin-induced diabetic rats

Increase of angiotensin-converting enzyme activity and peripheral sympathetic dysfunction could contribute to hypertension development in streptozotocin-induced diabetic rats

Author Musial, Diego C. Autor UNIFESP Google Scholar
Silva Junior, Edilson D. da Autor UNIFESP Google Scholar
Silva, Regiane M. da Autor UNIFESP Google Scholar
Miranda-Ferreira, Regiane Autor UNIFESP Google Scholar
Lima-Landman, M. Teresa R. Autor UNIFESP Google Scholar
Jurkiewicz, Aron Autor UNIFESP Google Scholar
Garcia, Antonio G. Google Scholar
Jurkiewicz, Neide H. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Autonoma Madrid
Hosp Univ La Princesa
Abstract Diabetes augments the risk of hypertension. Although several factors have been implicated in the development of such hypertensive state, we designed this study to investigate blood pressure development, the activity of angiotensin-converting enzyme (ACE) in blood as well as sympathetic neurotransmission in the vas deferens of diabetic rats. We used streptozotocin (STZ)-induced diabetic rats (60 mg/kg) in order to evaluate the systolic blood pressure (SBP), ACE activity and peripheral sympathetic neurotransmission. We observed the following changes of parameters: increase of SBP, decrease of heart rate, augmentation of plasma ACE activity, enhancement of phasic and tonic vas deferens contractions elicited by electrical stimulation at 5 Hz, increase of maximal response to noradrenaline (NA) and decrease of adenosine triphosphate (ATP)-elicited contraction of vasa deferentia. the results reveal that in the development of hypertension in diabetic rats, augmentation of circulating ACE activity precedes the sympathetic dysfunction. Additionally, it seems that the purinergic and noradrenergic neurotransmission is compromised.
Keywords Diabetes
hypertension
angiotensin-converting enzyme
sympathetic dysfunction
Language English
Date 2013-11-01
Published in Diabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 10, n. 6, p. 498-504, 2013.
ISSN 1479-1641 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 498-504
Origin http://dx.doi.org/10.1177/1479164113496441
Access rights Closed access
Type Article
Web of Science ID WOS:000325803800004
URI http://repositorio.unifesp.br/handle/11600/36966

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