Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Author Baiense, Robson Fantinato Autor UNIFESP Google Scholar
Abrahao, Agessandro Autor UNIFESP Google Scholar
Ricarte, Irapua F. Autor UNIFESP Google Scholar
Fukuda, Thiago G. Autor UNIFESP Google Scholar
Oliveira, Ricardo A. Autor UNIFESP Google Scholar
Silva, Gisele S. Autor UNIFESP Google Scholar
Costa, Maristela Google Scholar
Teixeira, Manoel J. Google Scholar
Institution Hosp Coracao
Universidade Federal de São Paulo (UNIFESP)
Abstract Alteplase (recombinant tissue plasminogen activator [rt-PA]) label approval by the Food and Drug Administration remarks the contraindication of its use with known intracranial neoplasm because of potential bleeding complications. Despite this concern, the real risk of intracerebral bleeding in patients with intracranial neoplasms treated with rt-PA is unknown, and there are few reports of thrombolysis in patients with brain tumors. We report a case of a 78-year-old man who was seen in our emergency department within 2 hours from sudden onset of aphasia, right-sided hemiplegia, hypoesthesia, and homonymous hemianopsia. the National Institutes of Health Stroke Scale (NIHSS) score at admission was 20. Intra-arterial thrombolysis was performed with administration of .3 mg/kg of alteplase combined with mechanical thrombectomy. At discharge, his NIHSS score was 1, and after 90 days, his modified Rankin score was 1. To our knowledge, this is the first report of intra-arterial thrombolysis in a patient with acute ischemic stroke with an intracranial tumor.
Keywords Intra-arterial thrombolysis
intracranial neoplasm
acute ischemic stroke
mechanical thrombectomy
intracranial hemorrhage
Language English
Date 2013-11-01
Published in Journal of Stroke & Cerebrovascular Diseases. Amsterdam: Elsevier B.V., v. 22, n. 8, p. E658-E660, 2013.
ISSN 1052-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent E658-E660
Access rights Closed access
Type Article
Web of Science ID WOS:000327719000066

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