Lithium Prevents REM Sleep Deprivation-Induced Impairments on Memory Consolidation

Lithium Prevents REM Sleep Deprivation-Induced Impairments on Memory Consolidation

Author Ota, Simone Marie Autor UNIFESP Google Scholar
Moreira, Karin Di Monteiro Autor UNIFESP Google Scholar
Suchecki, Deborah Autor UNIFESP Google Scholar
Oliveira, Maria Gabriela Menezes de Autor UNIFESP Google Scholar
Tiba, Paula Ayako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Abstract Background: Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave sleep (SWS). Given that both SWS and REMS appear to be important for memory processes, REMS rebound after training may disrupt the organization of sleep cycles, i.e., excessive amount of REMS and/or little SWS after training could be harmful for memory formation.Objective: To examine whether lithium, a drug known to increase SWS and reduce REMS, could prevent the memory impairment induced by pre-training sleep deprivation.Design: Animals were divided in 2 groups: cage control (CC) and REMS-deprived (REMSDep), and then subdivided into 4 subgroups, treated either with vehicle or 1 of 3 doses of lithium (50, 100, and 150 mg/kg) 2 h before training on the multiple trial inhibitory avoidance task. Animals were tested 48 h later to make sure that the drug had been already metabolized and eliminated. Another set of animals was implanted with electrodes and submitted to the same experimental protocol for assessment of drug-induced sleep-wake changes.Subjects: Wistar male rats weighing 300-400 g.Results: Sleep deprived rats required more trials to learn the task and still showed a performance deficit during test, except from those treated with 150 mg/kg of lithium, which also reduced the time spent in REM sleep during sleep recovery.Conclusion: Lithium reduced rapid eye movement sleep and prevented memory impairment induced by sleep deprivation. These results indicate that these phenomena may be related, but cause-effect relationship cannot be ascertained.
Keywords Multiple trial inhibitory avoidance task
slow wave sleep
sleep rebound
Language English
Date 2013-11-01
Published in Sleep. Westchester: Amer Acad Sleep Medicine, v. 36, n. 11, p. 1677-1684, 2013.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 1677-1684
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000326537800013

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