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dc.contributor.authorGirardi, Carlos Eduardo Neves [UNIFESP]
dc.contributor.authorTiba, Paula Ayako [UNIFESP]
dc.contributor.authorLlobet, Gisela B. [UNIFESP]
dc.contributor.authorLevin, Raquel [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.date.accessioned2016-01-24T14:34:34Z
dc.date.available2016-01-24T14:34:34Z
dc.date.issued2013-10-02
dc.identifierhttp://dx.doi.org/10.3389/fnbeh.2013.00134
dc.identifier.citationFrontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 7, 8 p., 2013.
dc.identifier.issn1662-5153
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36867
dc.description.abstractTraumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated emotional arousal in face of non-conditioned stimuli are among the most prominent features of PTSD. We hypothesized that long-term emotional alterations seen in PTSD may depend on the strength of context-trauma association. Here, we investigated the contribution of previous contextual exploration to the long-term emotional outcomes of an intense foot shock in rats. We exposed male Wistar rats to a highly stressful event (foot shock, 2 mA, 1 sec) allowing them to explore or not the chamber prior to trauma. We, then, evaluated the long-term effects on emotionality. Fear was assessed by the time spent in freezing behavior either upon re-exposure to trauma context or upon exposure to an unknown environment made potentially more aversive by presentation of an acoustic stimulus. Behaviors on the elevated-plus-maze and acoustic startle response were also assessed. the possibility to explore the environment immediately before the aversive event led to differential long-term emotional effects, including a heightened freezing response to re-exposure to context, blunted exploratory behavior, fear sensitization and exacerbation of the acoustic startle response, in contrast to the minor outcomes of the foot shock with no prior context exploration. the data showed the strong contribution of contextual learning to long-term behavioral effects of traumatic stress. We argue that contextual representation contributes to the robust long-term behavioral alterations seen in this model of traumatic stress.en
dc.description.sponsorshipAFIP (Associacao Fundo de Incentivo a Pesquisa)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent8
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Behavioral Neuroscience
dc.rightsAcesso aberto
dc.subjectcontext fear conditioningen
dc.subjectcontextual configurationen
dc.subjectPTSDen
dc.subjectemotional behavioren
dc.subjectpsychiatric disorderen
dc.subjectanimal modelen
dc.titleContextual exploration previous to an aversive event predicts long-term emotional consequences of severe stressen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Matemat Comp & Cognicao, SantoAndre, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, BR-04023062 São Paulo, Brazil
dc.identifier.fileWOS000325067700001.pdf
dc.identifier.doi10.3389/fnbeh.2013.00134
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000325067700001


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