Randomized Trial on the Effect of Sevoflurane on Polypropylene Membrane Oxygenator Performance

Date
2013-10-01Author
Neto, Caetano Nigro
Arnoni, Renato
Rida, Bilal Smaili
Landoni, Giovanni
Tardelli, Maria Angela [UNIFESP]
Type
ArtigoISSN
1053-0770Is part of
Journal of Cardiothoracic and Vascular AnesthesiaDOI
10.1053/j.jvca.2012.12.012Metadata
Show full item recordAbstract
Objectives: Volatile anesthetics have cardioprotective properties that improve clinically relevant outcomes in cardiac surgery, and can be used during cardiopulmonary bypass (CPB) through adapted calibrated vaporizers together with air and oxygen (O-2). the effect of volatile agents on the membrane oxygenator is unknown. the aim of this study was to evaluate, for the first time, the performance of semiporous polypropylene membrane oxygenators after the use of sevoflurane vaporized during CPB in cardiac surgery.Design: A prospective, randomized, controlled trial.Setting: Teaching hospital.Participants: Thirty-two consecutive patients scheduled to undergo coronary artery bypass graft with CPB.Interventions: Patients were allocated randomly to receive either a volatile anesthetic (sevoflurane 1%-3%, 16 patients) or an intravenous hypnotic (midazolam, 16 patients) during CPB. After surgery, the membrane oxygenators used during CPB were tested with regard to O-2 transfer, carbon dioxide transfer, and pressure drop.Measurements and Main Results: the authors observed no protocol deviation or crossover. the performance of the membrane oxygenator was similar between the 2 groups, as documented by O-2 transfer (55 +/- 6.4 mL/min/L in the sevoflurane group versus 57 +/- 4.7 mL/min/L in the midazolam group, p = 0.4), carbon dioxide transfer, and pressure drop.Conclusions: the use of sevoflurane during CPB in cardiac surgery does not affect membrane oxygenator performance. (C) 2013 Elsevier Inc. All rights reserved.
Citation
Journal of Cardiothoracic and Vascular Anesthesia. Philadelphia: W B Saunders Co-Elsevier Inc, v. 27, n. 5, p. 903-907, 2013.Keywords
cardiopulmonary bypassanesthesia
drugs
evaluation
membrane oxygenator
gas transfer
oxygen
sevoflurane
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