Polyphenols as a chemopreventive agent in oral carcinogenesis: putative mechanisms of action using in-vitro and in-vivo test systems

Polyphenols as a chemopreventive agent in oral carcinogenesis: putative mechanisms of action using in-vitro and in-vivo test systems

Author Moura, Carolina Foot Gomes de Autor UNIFESP Google Scholar
Noguti, Juliana Autor UNIFESP Google Scholar
Jesus, Gustavo Protasio Pacheco de Autor UNIFESP Google Scholar
Ribeiro, Flavia Andressa Pidone Autor UNIFESP Google Scholar
Garcia, Fernanda Asprón Autor UNIFESP Google Scholar
Gollucke, Andrea Pittelli Boiago Autor UNIFESP Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Catolica Santos
Abstract Polyphenols are present in foods and beverages, being related to sensorial qualities such as color, bitterness, and astringency, which are relevant in products such as wine, tea, and grape juice. These compounds occur naturally in forms varying from simple phenolic acids to complex polymerized tannins. Oral cancer is the most common head and neck cancer, and it often has a poor prognosis owing to local tumor invasion and frequent lymph node metastasis. Nowadays, chemoprevention is considered as a promising approach for controlling cancer as a result of specific natural products or synthetic agents able to suppress, reverse, or even prevent premalignancy before transformation into invasive cancer. the use of polyphenols as a chemopreventive agent is a suitable tool for modulation of the oral carcinogenesis process. the aim of this article is to present data generated from the use of polyphenols as a chemopreventive agent in oral carcinogenesis using in-vivo and in-vitro test systems. These results have shown that polyphenols are able to exert some chemopreventive action as a result of inducing cellular death, apoptosis, inhibition of tumor growth, and antioxidative properties. Therefore, this area warrants further investigation as a new approach that would apply not only to polyphenols but also to other phytochemicals used as promising therapeutic agents against oral human diseases, especially cancer. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Keywords Chemoprevention
Oral cancer
Polyphenol
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-09-01
Published in European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, v. 22, n. 5, p. 467-472, 2013.
ISSN 0959-8278 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 467-472
Origin https://dx.doi.org/10.1097/CEJ.0b013e32835b6a94
Access rights Closed access
Type Article
Web of Science ID WOS:000323226200014
URI https://repositorio.unifesp.br/handle/11600/36727

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account