Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

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dc.contributor.author Lopes Albuquerque, Ivan Rui
dc.contributor.author Cordeiro, Sara Lima
dc.contributor.author Gomes, Dayanne Lopes
dc.contributor.author Dreyfuss, Juliana Luporini [UNIFESP]
dc.contributor.author Alves Filgueira, Luciana Guimaraes
dc.contributor.author Leite, Edda Lisboa
dc.contributor.author Nader, Helena Bonciani [UNIFESP]
dc.contributor.author Oliveira Rocha, Hugo Alexandre
dc.date.accessioned 2016-01-24T14:32:02Z
dc.date.available 2016-01-24T14:32:02Z
dc.date.issued 2013-08-01
dc.identifier http://dx.doi.org/10.3390/md11082722
dc.identifier.citation Marine Drugs. Basel: Mdpi Ag, v. 11, n. 8, p. 2722-2740, 2013.
dc.identifier.issn 1660-3397
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36572
dc.description.abstract Fucan is a term that defines a family of homo-and hetero-polysaccharides containing sulfated L-fucose in its structure. in this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-alpha). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. in summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte-FAPERN
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Ministerio de Ciencia, Tecnologia e Inovacao-MCTI
dc.format.extent 2722-2740
dc.language.iso eng
dc.publisher Mdpi Ag
dc.relation.ispartof Marine Drugs
dc.rights Acesso aberto
dc.subject fucan en
dc.subject brown seaweed en
dc.subject pain en
dc.subject analgesic en
dc.subject dictyotales en
dc.title Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis en
dc.type Artigo
dc.contributor.institution Fed Univ Rio Grande Norte UFRN
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ Rio Grande Norte UFRN, Dept Biochem, Lab Biotechnol Nat Polymers BIOPOL, BR-59078970 Natal, RN, Brazil
dc.description.affiliation Fed Univ Rio Grande Norte UFRN, Grad Program Hlth Sci, BR-59078970 Natal, RN, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Biochem, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Biochem, BR-04044020 São Paulo, Brazil
dc.identifier.file WOS000330521300003.pdf
dc.identifier.doi 10.3390/md11082722
dc.description.source Web of Science
dc.identifier.wos WOS:000330521300003



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