Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

Author Lopes Albuquerque, Ivan Rui Google Scholar
Cordeiro, Sara Lima Google Scholar
Gomes, Dayanne Lopes Google Scholar
Dreyfuss, Juliana Luporini Autor UNIFESP Google Scholar
Alves Filgueira, Luciana Guimaraes Google Scholar
Leite, Edda Lisboa Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Oliveira Rocha, Hugo Alexandre Google Scholar
Institution Fed Univ Rio Grande Norte UFRN
Universidade Federal de São Paulo (UNIFESP)
Abstract Fucan is a term that defines a family of homo-and hetero-polysaccharides containing sulfated L-fucose in its structure. in this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-alpha). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. in summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.
Keywords fucan
brown seaweed
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte-FAPERN
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ministerio de Ciencia, Tecnologia e Inovacao-MCTI
Date 2013-08-01
Published in Marine Drugs. Basel: Mdpi Ag, v. 11, n. 8, p. 2722-2740, 2013.
ISSN 1660-3397 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent 2722-2740
Origin http://dx.doi.org/10.3390/md11082722
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000330521300003
URI http://repositorio.unifesp.br/handle/11600/36572

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