Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice

Kameda, Sonia R. [UNIFESP]; Fukushiro, Daniela F. [UNIFESP]; Wuo-Silva, Raphael [UNIFESP]; Trombin, Thais F. [UNIFESP]; Procopio-Souza, Roberta [UNIFESP]; Brandao, Leticia C. [UNIFESP]; Sanday, Leandro [UNIFESP]; Patti, Camilla L. [UNIFESP]; Mari-Kawamoto, Elisa [UNIFESP]; Tufik, Sergio [UNIFESP]; D'Almeida, Vania [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]

Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice

Data

2013-06-30

Autores

Kameda, Sonia R.

Fukushiro, Daniela F.

Wuo-Silva, Raphael

Trombin, Thais F.

Procopio-Souza, Roberta

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Artigo

Resumo

We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Citação

Psychiatry Research. Clare: Elsevier B.V., v. 208, n. 1, p. 74-77, 2013.