Does menopause influence nocturnal awakening with headache?

Does menopause influence nocturnal awakening with headache?

Author Lucchesi, Ligia Mendonça Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Yagihara, Fabiana Tokie Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective the aim of the present study was to assess whether menopausal status influences the occurrence of nocturnal awakening with headache (NAH) in the female population of São Paulo, Brazil. We also examined the relationship of this complaint to sociodemographic determinants, hot flushes, sleep quality and parameters, anxiety and depressive symptoms, somnolence and fatigue according to menopausal status.Methods the female population of the São Paulo Epidemiologic Sleep Study (EPISONO) (n = 576) was divided according to menopausal status (pre-, peri-, early and late menopause) based on questionnaires and hormonal blood measures. the complaint of waking up because of a headache at least once a week was assessed by the UNIFESP Sleep questionnaire. Additionally, hot flushes, sleep complaints, anxiety and depressive symptoms, somnolence and fatigue were assessed by specific questionnaires. A full-night polysomnography assessed sleep parameters.Results the prevalence of NAH in women in the São Paulo population was 13.3%. Perimenopause was associated with a higher risk of having NAH (odds ratio 13.9; 95% confidence interval 4.3-45.2). More complaints of NAH were observed in obese women. All the groups with NAH showed more hot flushes, worse subjective sleep quality, more complaints of insomnia, anxiety symptoms and fatigue.Conclusions We observed a constellation of symptoms in women according to menopausal status and NAH that included hot flushes, sleep complaints, more anxiety symptoms and fatigue. Moreover, some of these symptoms were more frequent in perimenopausal women with NAH. Therefore, we concluded that menopausal status influences NAH and the women in perimenopause presented a high risk of having this complaint.
Keywords Nocturnal awakening
Headache
Women
Menopause
Hot flushes
Sleep
Insomnia
Fatigue
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/50525-1
FAPESP: 98/14303-3
Date 2013-06-01
Published in Climacteric. London: Informa Healthcare, v. 16, n. 3, p. 362-368, 2013.
ISSN 1369-7137 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 362-368
Origin https://dx.doi.org/10.3109/13697137.2012.717997
Access rights Closed access
Type Article
Web of Science ID WOS:000318937600008
URI https://repositorio.unifesp.br/handle/11600/36419

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