Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy

Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy

Author Pereira, Tatiana Araujo Google Scholar
Teixeira da Silva, Gisele Espinha Google Scholar
Hernandez, Raul Bonne Autor UNIFESP Google Scholar
Forti, Fabio Luis Google Scholar
Esposito, Breno Pannia Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Manganese (Mn) is an essential trace element and trivalent Mn complexes have been used as oxidation catalysts and enzyme mimetics. We studied the cytotoxicity of Mn(III) derivatives of citrate, pyrophosphate and salicylene diamine (respectively, MnCit, MnPPi and EUK8) toward HeLa cells stressed by ultraviolet irradiation and the effect of the co-administration of ascorbate and para-amino salicylate (PAS) on cell viability. Metal complexes enhanced the lethality of irradiated cells, and this effect was even more pronounced when ascorbate was co-administered with Mn(III) species. the active role of Mn(III) compounds in the antitumor activity was demonstrated by the treatment of the cells with the chelator PAS, which restored the viability of both non-irradiated and UV-irradiated cells. the association of the Mn(III) metallodrugs with radiation and an antioxidant proved to be a very effective approach to chemotherapy.
Keywords Manganese
Ascorbate
HeLa
Ultraviolet
Stress
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 471400/2011-4
FAPESP: 2011/50318-1
Date 2013-06-01
Published in Biometals. Dordrecht: Springer, v. 26, n. 3, p. 439-446, 2013.
ISSN 0966-0844 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 439-446
Origin http://dx.doi.org/10.1007/s10534-013-9626-2
Access rights Closed access
Type Article
Web of Science ID WOS:000320374100006
URI http://repositorio.unifesp.br/handle/11600/36381

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