Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

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dc.contributor.author Gomes, Caio Perez [UNIFESP]
dc.contributor.author Torloni, Maria Regina [UNIFESP]
dc.contributor.author Gueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
dc.contributor.author Alexandre, Sandra Maria [UNIFESP]
dc.contributor.author Mattar, Rosiane [UNIFESP]
dc.contributor.author Daher, Silvia [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:48Z
dc.date.available 2016-01-24T14:31:48Z
dc.date.issued 2013-06-01
dc.identifier http://dx.doi.org/10.1111/aji.12088
dc.identifier.citation American Journal of Reproductive Immunology. Hoboken: Wiley-Blackwell, v. 69, n. 6, p. 545-557, 2013.
dc.identifier.issn 1046-7408
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36364
dc.description.abstract Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of Study Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. Results Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD=0.45, 95% CI 0.341.23). Conclusions New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 545-557
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof American Journal of Reproductive Immunology
dc.rights Acesso aberto
dc.subject Blood specimen collection en
dc.subject cytokines en
dc.subject gestational diabetes mellitus en
dc.subject inflammation en
dc.subject physiopathology en
dc.title Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature en
dc.type Resenha
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Obstet, BR-01415002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Obstet, BR-01415002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: FAPESP - 10/52547-5
dc.identifier.doi 10.1111/aji.12088
dc.description.source Web of Science
dc.identifier.wos WOS:000318758800004



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