Resistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophy

Resistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophy

Author Mônico-Neto, Marcos Autor UNIFESP Google Scholar
Antunes, Hanna Karen Moreira Autor UNIFESP Google Scholar
Dattilo, Murilo Autor UNIFESP Google Scholar
Medeiros, Alessandra Autor UNIFESP Google Scholar
Souza, Heitor Soares de Autor UNIFESP Google Scholar
Lee, Kil Sun Autor UNIFESP Google Scholar
Melo, Camila Maria de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
CEPE
Abstract Sleep is important for maintenance of skeletal muscle health. Sleep debt can induce muscle atrophy by increasing glucocorticoids and decreasing testosterone, growth hormone and insulin-like growth factor-I. These hormonal alterations result in a highly proteolytic environment characterized by decreased protein synthesis and increased degradation. Given that sleep deprivation is increasingly prevalent in modern society, strategies to minimize or reverse its adverse effects need to be investigated. Resistance exercise has been suggested as an intervention that would benefit the muscle health. the practice of this type of exercise can increase the concentration of testosterone, growth hormone and insulin-like growth factor I and stimulate the protein synthesis through a key signaling molecule, mammalian target of rapamycin. Thus, we hypothesized that resistance exercise is an important non-pharmacological strategy to counteract deleterious effects of sleep debt on skeletal muscle. (C) 2013 Elsevier B.V. All rights reserved.
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Centro de Estudos em Psicobiologia e Exercicio (CEPE)
Centro de Estudo Multidisciplinar em Sonolencia e Acidentes (CEMSA)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
UNIFESP
Fundo de Auxilio aos Docentes e Alunos (FADA)
Grant number FAPESP: 98/14303-3
FAPESP: 11/15962-7
Date 2013-06-01
Published in Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 80, n. 6, p. 701-705, 2013.
ISSN 0306-9877 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 701-705
Origin http://dx.doi.org/10.1016/j.mehy.2013.02.013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000319634800004
URI http://repositorio.unifesp.br/handle/11600/36359

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