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dc.contributor.authordas Neves, Vander Jose
dc.contributor.authorTanno, Ana Paula
dc.contributor.authorCunha, Tatiana Sousa [UNIFESP]
dc.contributor.authorFernandes, Tiago
dc.contributor.authorGuzzoni, Vinicius
dc.contributor.authorSilva, Carlos Alberto da
dc.contributor.authorOliveira, Edilamar Menezes de
dc.contributor.authorCosta Sampaio Moura, Maria Jose
dc.contributor.authorMarcondes, Fernanda Klein
dc.date.accessioned2016-01-24T14:31:48Z
dc.date.available2016-01-24T14:31:48Z
dc.date.issued2013-05-30
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2013.04.002
dc.identifier.citationLife Sciences. Oxford: Pergamon-Elsevier B.V., v. 92, n. 20-21, p. 1029-1035, 2013.
dc.identifier.issn0024-3205
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36353
dc.description.abstractAims: This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the beta(1)- and beta(2)-adrenergic receptors in the heart of rats.Main methods: Wistar rats were randomly divided into four groups and submitted to a 6-week treatment with nandrolone and/or resistance training. Cardiac hypertrophy was accessed by the ratio of heart weight to the final body weight. Blood pressure was determined by a computerized tail-cuff system. Electrocardiography analyses were performed. Western blotting was used to access the protein levels of the beta(1)- and beta(2)-adrenergic receptors in the right atrium and left ventricle.Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased systolic blood pressure depending on the treatment time. Resistance training decreased systolic, diastolic and mean arterial blood pressure, as well as induced resting bradycardia. Nandrolone prolonged the QTc interval for both trained and non-trained groups when they were compared to their respective vehicle-treated one. Nandrolone increased the expression of beta(1)- and beta(2)-adrenergic receptors in the right atrium for both trained and non-trained groups when they were compared to their respective vehicle-treated one.Significance: This study indicated that nandrolone, associated or not with resistance training increases blood pressure depending on the treatment time, induces prolongation of the QTc interval, and increases the expression of beta(1)- and beta(2)-adrenergic receptors in the cardiac right atrium, but not in the left ventricle. (c) 2013 Published by Elsevier Inc.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFAEPEX/UNICAMP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1029-1035
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLife Sciences
dc.rightsAcesso restrito
dc.subjectCardiac hypertrophyen
dc.subjectArterial blood pressureen
dc.subjectElectrocardiographyen
dc.subjectTrainingen
dc.subjectAnabolic steroidsen
dc.subjectBeta-adrenergic receptorsen
dc.titleEffects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of atrial beta-adrenergic receptorsen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Metodista Piracicaba
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Sci & Technol, São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sports, Biochem Lab, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Metodista Piracicaba, Piracicaba, SP, Brazil
dc.description.affiliationPontifical Cathol Univ Campinas, Life Sci Ctr, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Sci & Technol, São Paulo, SP, Brazil
dc.identifier.doi10.1016/j.lfs.2013.04.002
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000319853600011


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