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dc.contributor.authorAlves Nunes, Luciana Vargas [UNIFESP]
dc.contributor.authorLacaz, Fernando Sargo [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorVargas Alves Nunes, Sandra Odebrecht
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.date.accessioned2016-01-24T14:31:33Z
dc.date.available2016-01-24T14:31:33Z
dc.date.issued2013-04-01
dc.identifierhttp://dx.doi.org/10.1111/jsm.12040
dc.identifier.citationJournal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 10, n. 4, p. 1136-1145, 2013.
dc.identifier.issn1743-6095
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36186
dc.description.abstractIntroduction. Evidence is accumulating to support the presence of erectile dysfunction in patients with schizophrenia. This dysregulation may be amenable to therapeutic intervention to improve adherence and quality of life of patients who suffer from schizophrenia and schizoaffective disorders. Aim. We aimed to evaluate the use of adjunctive medication lodenafil for the treatment of erectile dysfunction in outpatients with schizophrenia and spectrum. Methods. the design was a randomized, double-blind, crossover, placebo-controlled trial with lodenafil and it was carried at the Schizophrenia Outpatients Program. Main Outcome Measures. the measures used to assess sexual dysfunction were Arizona Sexual Experiences Scale (ASEX) and International Index of Erectile Function (IIEF). the Positive and Negative Syndrome Scale (PANSS) and the Quality of Life Scale (QLS) were also used. the measures included the levels of prolactin, estradiol, luteinizing hormone, sex hormone-binding globulin, free testosterone, and total testosterone at baseline and end point. Lodenafil and placebo pills were used by the patients for 16 weeks. Results. Fifty male outpatients fulfilled the criteria and 94% of the participants completed the study. Lodenafil and placebo produced improvement in ASEX, IIEF scale, PANSS, and QLS, and there was no statistical difference between lodenafil and placebo groups in all sexual domains in the results of PANSS and QLS and in the results of hormone levels. Conclusion. These results indicate that both lodenafil and placebo were effective in the treatment of erectile dysfunction for schizophrenia. Placebo effect is very important in patients with schizophrenia and this study showed the importance of discussing sexuality and trying to treat these patients. Further studies designed to test treatments of erectile dysfunction in patients who suffer from schizophrenia are necessary. Nunes LVA, Lacaz FS, Bressan RA, Nunes SOVA, and Mari JJ. Adjunctive treatment with lodenafil carbonate for erectile dysfunction in outpatients with schizophrenia and spectrum: A randomized, double-blind, crossover, placebo-controlled trial. J Sex Med 2013; 10: 1136-1145.en
dc.format.extent1136-1145
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Sexual Medicine
dc.rightsAcesso restrito
dc.subjectSchizophreniaen
dc.subjectErectile Dysfunctionen
dc.subjectTreatmenten
dc.subjectCrossover Trialen
dc.subjectPlaceboen
dc.subjectLodenafil Carbonateen
dc.subjectAntipsychoticen
dc.titleAdjunctive Treatment with Lodenafil Carbonate for Erectile Dysfunction in Outpatients with Schizophrenia and Spectrum: A Randomized, Double-Blind, Crossover, Placebo-Controlled Trialen
dc.typeArtigo
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Estadual Londrina, Dept Clin Med, BR-86050190 Londrina, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.identifier.doi10.1111/jsm.12040
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000317008100023


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