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dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorBelangero, Sintia I. [UNIFESP]
dc.contributor.authorSpindola, Leticia M. [UNIFESP]
dc.contributor.authorRocha, Natalia Pessoa
dc.contributor.authorMiranda, Aline Silva de
dc.contributor.authorTeixeira, Antonio Lucio
dc.contributor.authorCardoso Smith, Marilia Arruda [UNIFESP]
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.date.accessioned2016-01-24T14:31:31Z
dc.date.available2016-01-24T14:31:31Z
dc.date.issued2013-04-01
dc.identifierhttp://dx.doi.org/10.1016/j.jpsychires.2012.12.010
dc.identifier.citationJournal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 47, n. 4, p. 467-471, 2013.
dc.identifier.issn0022-3956
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36162
dc.description.abstractBackground: Schizophrenia (SZ) has been associated with an imbalance in the inflammatory cytokine TNF-alpha. the objectives of this study were to compare TNF-alpha and its soluble receptors' serum levels in individuals with SZ with the levels found in a group of healthy volunteers and to investigate the possible association between these biomarkers and the dimensions and severity of symptoms, clinical outcomes and response to treatment in patients with SZ.Methods: Fifty-four chronically medicated SZ outpatients and 118 healthy controls were included in the study. TNF-alpha levels were measured by Cytometric Bead Assay (CBA), and serum levels of soluble tumor necrosis factor receptor 1 (sTNFR1) and soluble tumor necrosis factor receptor 2 (sTNFR2) were measured by ELISA.Results: sTNFR1 and sTNFR2 were significantly elevated in patients with SZ as compared to the healthy control group. in the group of individuals with SZ, the levels of both types of soluble TNF receptors showed a negative correlation with global functioning. sTNFR1 levels were higher in the treatment-resistant patients as compared to the non-treatment-resistant patients and the controls. sTNFR1 levels were also heightened in patients with SZ and concomitant depression.Conclusion: Our findings reinforce that SZ is associated with an inflammatory profile and suggest that sTNFR1 is a marker of a treatment-resistance and severe clinical course in SZ. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent467-471
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Psychiatric Research
dc.rightsAcesso restrito
dc.subjectSchizophreniaen
dc.subjectBiomarkersen
dc.subjectImmune systemen
dc.subjectInflammationen
dc.subjectTNF-alphaen
dc.subjectTNF-alpha receptorsen
dc.titleCirculating levels of sTNFR1 as a marker of severe clinical course in schizophreniaen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Program Schizophrenia PROESQ, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, LINC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Genet, São Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Translat Psychoneuroimmunol Grp, Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Program Schizophrenia PROESQ, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, LINC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Genet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi10.1016/j.jpsychires.2012.12.010
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000317027700006


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