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Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia

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Date
2013-04-01
Author
Noto, Cristiano [UNIFESP]
Gadelha, Ary [UNIFESP]
Belangero, Sintia I. [UNIFESP]
Spindola, Leticia M. [UNIFESP]
Rocha, Natalia Pessoa
Miranda, Aline Silva de
Teixeira, Antonio Lucio
Cardoso Smith, Marilia Arruda [UNIFESP]
Mari, Jair de Jesus [UNIFESP]
Bressan, Rodrigo Affonseca [UNIFESP]
Brietzke, Elisa [UNIFESP]
Type
Artigo
ISSN
0022-3956
Is part of
Journal of Psychiatric Research
DOI
10.1016/j.jpsychires.2012.12.010
Metadata
Show full item record
Abstract
Background: Schizophrenia (SZ) has been associated with an imbalance in the inflammatory cytokine TNF-alpha. the objectives of this study were to compare TNF-alpha and its soluble receptors' serum levels in individuals with SZ with the levels found in a group of healthy volunteers and to investigate the possible association between these biomarkers and the dimensions and severity of symptoms, clinical outcomes and response to treatment in patients with SZ.Methods: Fifty-four chronically medicated SZ outpatients and 118 healthy controls were included in the study. TNF-alpha levels were measured by Cytometric Bead Assay (CBA), and serum levels of soluble tumor necrosis factor receptor 1 (sTNFR1) and soluble tumor necrosis factor receptor 2 (sTNFR2) were measured by ELISA.Results: sTNFR1 and sTNFR2 were significantly elevated in patients with SZ as compared to the healthy control group. in the group of individuals with SZ, the levels of both types of soluble TNF receptors showed a negative correlation with global functioning. sTNFR1 levels were higher in the treatment-resistant patients as compared to the non-treatment-resistant patients and the controls. sTNFR1 levels were also heightened in patients with SZ and concomitant depression.Conclusion: Our findings reinforce that SZ is associated with an inflammatory profile and suggest that sTNFR1 is a marker of a treatment-resistance and severe clinical course in SZ. (C) 2013 Elsevier B.V. All rights reserved.
Citation
Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 47, n. 4, p. 467-471, 2013.
Keywords
Schizophrenia
Biomarkers
Immune system
Inflammation
TNF-alpha
TNF-alpha receptors
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
URI
http://repositorio.unifesp.br/handle/11600/36162
Collections
  • Em verificação - Geral [10999]

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