Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats
Data
2013-03-05
Autores
Renno, Ana Claudia Muniz 
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Introduction: the effects of LLLT were studied during muscle regeneration through gene expression.Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression.Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). the MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days.Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved.
Descrição
Citação
Journal of Photochemistry and Photobiology B-biology. Lausanne: Elsevier Science Sa, v. 120, p. 29-35, 2013.