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dc.contributor.authorAlmeida, Valéria de [UNIFESP]
dc.contributor.authorLevin, Raquel [UNIFESP]
dc.contributor.authorPeres, Fernanda Fiel [UNIFESP]
dc.contributor.authorNiigaki, Suzy Tamie [UNIFESP]
dc.contributor.authorCalzavara, Mariana Bendlin [UNIFESP]
dc.contributor.authorZuardi, Antonio Waldo
dc.contributor.authorHallak, Jaime Eduardo Cecilio
dc.contributor.authorCrippa, José Alexandre de Souza
dc.contributor.authorAbílio, Vanessa Costhek [UNIFESP]
dc.date.accessioned2016-01-24T14:31:23Z
dc.date.available2016-01-24T14:31:23Z
dc.date.issued2013-03-05
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2012.10.024
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 41, p. 30-35, 2013.
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36076
dc.description.abstractCannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. in addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. the aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. the lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent30-35
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsAcesso aberto
dc.subjectAnxietyen
dc.subjectCannabidiolen
dc.subjectSchizophreniaen
dc.subjectSHRen
dc.subjectSocial interaction testen
dc.titleCannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction testen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Nacl Ciencia & Tecnol Translac Med
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, UNIFESP, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationInst Nacl Ciencia & Tecnol Translac Med, INCT TM, CNPq, Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: FAPESP - 2010/07994-3
dc.identifier.fileWOS000315324600006.pdf
dc.identifier.doi10.1016/j.pnpbp.2012.10.024
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000315324600006


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