Drusen detection by confocal aperture-modulated infrared scanning laser ophthalmoscopy

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dc.contributor.author Diniz, Bruno [UNIFESP]
dc.contributor.author Ribeiro, Ramiro M.
dc.contributor.author Rodger, Damien C.
dc.contributor.author Maia, Mauricio [UNIFESP]
dc.contributor.author Sadda, SriniVas
dc.date.accessioned 2016-01-24T14:31:22Z
dc.date.available 2016-01-24T14:31:22Z
dc.date.issued 2013-03-01
dc.identifier http://dx.doi.org/10.1136/bjophthalmol-2012-302575
dc.identifier.citation British Journal of Ophthalmology. London: Bmj Publishing Group, v. 97, n. 3, p. 285-290, 2013.
dc.identifier.issn 0007-1161
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36064
dc.description.abstract Aim To evaluate the efficiency of drusen detection by scanning laser ophthalmoscopy (SLO) using various infrared confocal apertures and differential contrast (DC) strategies.Methods 11 eyes with non-neovascular age-related macular degeneration (AMD) underwent infrared imaging with a Nidek F-10 confocal SLO using multiple confocal apertures: central, ring, aperture on the right side (AR) and left side (AL), with and without use of the DC. A conventional colour fundus photograph was also obtained. Images were exported into a certified grading tool and all visible drusen were manually outlined by two graders. for each image type, the number of drusen and total drusen area were calculated, and the measurements obtained by the two graders were averaged. Intergrader reliability was evaluated, and paired t tests compared measurements between the various aperture/DC modes and the colour image.Results Agreement between graders was high (r=0.93-0.98). Drusen number values obtained with the AR (121.0, p=0.01) mode were higher than for the colour photographs (69.1). Area measurements were also significantly higher in the AR (1.93 mm(2); p=0.04) and AL modes (1.41 mm(2); p=0.03) when compared with the colour photographs (1.24 mm(2)). the addition of the DC did not seem to improve drusen detection compared with the unmodified infrared images.Conclusions in this pilot study, drusen number and area grades were significantly higher using the AR and AL in which the laterally scattered light is captured (retromode). Use of the lateral confocal aperture may highlight subclinical drusen and aid in monitoring disease progression and response to emerging non-neovascular AMD therapies. en
dc.description.sponsorship NEI
dc.description.sponsorship Beckman Institute for Macular Research
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 285-290
dc.language.iso eng
dc.publisher Bmj Publishing Group
dc.relation.ispartof British Journal of Ophthalmology
dc.rights Acesso restrito
dc.title Drusen detection by confocal aperture-modulated infrared scanning laser ophthalmoscopy en
dc.type Artigo
dc.contributor.institution Doheny Eye Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Evangel Curitiba
dc.contributor.institution Univ So Calif
dc.description.affiliation Doheny Eye Inst, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliation Hosp Evangel Curitiba, Curitiba, Parana, Brazil
dc.description.affiliation Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.identifier.doi 10.1136/bjophthalmol-2012-302575
dc.description.source Web of Science
dc.identifier.wos WOS:000315162500010


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