Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy

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dc.contributor.author Patriarca, Marisa Teresinha [UNIFESP]
dc.contributor.author Barbosa de Moraes, Andrea Regina [UNIFESP]
dc.contributor.author Nader, Helena B. [UNIFESP]
dc.contributor.author Petri, Valeria [UNIFESP]
dc.contributor.author Maciel Martins, Joao Roberto [UNIFESP]
dc.contributor.author Teixeira Gomes, Regina Celia [UNIFESP]
dc.contributor.author Soares, Jose Maria [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:21Z
dc.date.available 2016-01-24T14:31:21Z
dc.date.issued 2013-03-01
dc.identifier http://dx.doi.org/10.1097/gme.0b013e318269898c
dc.identifier.citation Menopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 20, n. 3, p. 336-341, 2013.
dc.identifier.issn 1072-3714
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36050
dc.description.abstract Objective: the aim of this work was to compare the effects of estradiol and genistein treatment on hyaluronic acid (HA) concentration in postmenopausal facial skin.Methods: in this study, 30 postmenopausal women were evaluated in a prospective, randomized, double-blind trial. the volunteers were postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. the participants were divided into two groups: group E, treated with 0.01% 17 beta-estradiol gel (n = 15), and group G, treated with 4% genistein gel (isoflavones, n = 15). the treatment lasted for 24 consecutive weeks. Preauricular skin biopsies were performed for each participant at baseline (E1 and G1) and after treatment (E2 and G2) to evaluate HA concentration in tissue. the materials were processed using immunohistochemical and biochemical methods.Results: After 24 weeks of treatment, HA concentration increased in both groups, but the effect was greater for estradiol treatment than for genistein treatment.Conclusions: Our data suggest that both treatments may enhance HA concentration in postmenopausal skin but that estrogen produces results that are greater than those produced by isoflavones. en
dc.description.sponsorship Consejo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Funda cao de Amparo a Pesquisa do Estado de São Paulo
dc.format.extent 336-341
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Menopause-the Journal of the North American Menopause Society
dc.rights Acesso restrito
dc.subject Postmenopausal skin en
dc.subject Genistein gel en
dc.subject 17 beta-Estradiol gel en
dc.subject Hyaluronic acid en
dc.title Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Div Mol Biol, Dept Biochem, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Internal Med, Div Endocrinol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Div Mol Biol, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Internal Med, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sponsorshipID Funda cao de Amparo a Pesquisa do Estado de São Paulo: 2011/12417-8
dc.identifier.doi 10.1097/gme.0b013e318269898c
dc.description.source Web of Science
dc.identifier.wos WOS:000315603200017



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