Nitric oxide donor superparamagnetic iron oxide nanoparticles

Nitric oxide donor superparamagnetic iron oxide nanoparticles

Author Molina, Miguel M. Google Scholar
Seabra, Amedea B. Autor UNIFESP Google Scholar
Oliveira, Marcelo G. de Google Scholar
Itri, Rosangela Google Scholar
Haddad, Paula S. Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract This work reports a new strategy for delivering nitric oxide (NO), based on magnetic nanoparticles (MNPs), with great potential for biomedical applications. Water-soluble magnetic nanoparticles were prepared through a co-precipitation method by using ferrous and ferric chlorides in acidic solution, followed by a mercaptosuccinic acid (MSA) coating. the thiolated nanoparticles (SH-NPs) were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). the results showed that the SH-NPs have a mean diameter of 10 nm and display superparamagnetic behavior at room temperature. Free thiol groups on the magnetite surface were nitrosated through the addition of an acidified nitrite solution, yielding nitrosated magnetic nanoparticles (SNO-NPs). the amount of NO covalently bound to the nanoparticles surface was evaluated by chemiluminescense. the SNO-NPs spontaneously released NO in aqueous solution at levels required for biomedical applications. This new magnetic NO-delivery vehicle has a great potential to generate desired amounts of NO directed to the target location. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Magnetite nanoparticles
Nitric oxide
Iron oxide nanoparticles
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: nr. 2001/10125-0
CNPq: nr. 310209/2010
CNPq: 309390/ 2011-7
Date 2013-03-01
Published in Materials Science & Engineering C-materials for Biological Applications. Amsterdam: Elsevier B.V., v. 33, n. 2, p. 746-751, 2013.
ISSN 0928-4931 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 746-751
Access rights Closed access
Type Article
Web of Science ID WOS:000315761700025

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