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dc.contributor.authorLobo, Thalita Frutuoso [UNIFESP]
dc.contributor.authorTorloni, Maria Regina [UNIFESP]
dc.contributor.authorGueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
dc.contributor.authorMattar, Rosiane [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.date.accessioned2016-01-24T14:31:20Z
dc.date.available2016-01-24T14:31:20Z
dc.date.issued2013-03-01
dc.identifierhttp://dx.doi.org/10.1016/j.jri.2012.10.004
dc.identifier.citationJournal of Reproductive Immunology. Clare: Elsevier B.V., v. 97, n. 1, p. 120-127, 2013.
dc.identifier.issn0165-0378
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36036
dc.description.abstractGestational diabetes (GD) exposes mothers and infants to the risk of immediate and later adverse outcomes. Increased insulin resistance is a common feature of GD and obesity. Because of its critical role in regulating insulin sensitivity, resistin has been implicated in the physiopathology of GD. the aim of this study was to review the existing literature on the relationship between circulating maternal resistin levels and GD. Three electronic databases (MEDLINE, EMBASE, and LILACS) were searched for pertinent studies published from 2001 to 2012, without language restrictions. Eleven studies, with a total of 639 participants between 23 and 41 weeks of gestation, were included. the number of GD patients per study ranged from 11 to 81, with varying degrees of disease severity and several different GD diagnostic criteria. Mean concentrations of resistin varied widely both in control women (0.05-22.21 ng/ml) and in GD patients (0.05-62.38 ng/ml). We performed a meta-analysis including a total of 10 studies, and also subgroup analyses according to gestational age at sample collection (up to 32 and >33 weeks). the pooled absolute mean difference (WMD) in resistin levels was slightly lower in GD patients than in controls, but this did not reach statistical significance (WMD = -0.02,95% CI -0.07 to 0.04). According to the, data from the 11 studies analyzed, there was no association between circulating resistin levels and GD. However, this result should be interpreted with caution owing to the large heterogeneity amongst the existing published studies. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en
dc.format.extent120-127
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Reproductive Immunology
dc.rightsAcesso restrito
dc.subjectGestational diabetesen
dc.subjectResistinen
dc.subjectInsulin resistanceen
dc.subjectAdipokinesen
dc.titleResistin concentration and gestational diabetes: a systematic review of the literatureen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.identifier.doi10.1016/j.jri.2012.10.004
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000316434100015


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