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dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorvan de Watering, F. C. J.
dc.contributor.authorNejadnik, M. R.
dc.contributor.authorCrovace, Murilo Camuri
dc.contributor.authorZanotto, Edgar Dutra
dc.contributor.authorWolke, J. G. C.
dc.contributor.authorJansen, J. A.
dc.contributor.authorvan den Beucken, Jeroen J. J. P.
dc.identifier.citationActa Biomaterialia. Oxford: Elsevier B.V., v. 9, n. 3, p. 5728-5739, 2013.
dc.description.abstractBioactive glasses (BGs) are known for their unique ability to bond to living bone. Consequently, the incorporation of BGs into calcium phosphate cement (CPC) was hypothesized to be a feasible approach to improve the biological performance of CPC. Previously, it has been demonstrated that BGs can successfully be introduced into CPC, with or without poly(D,L-lactic-co-glycolic) acid (PLGA) microparticles. Although an in vitro physicochemical study on the introduction of BG into CPC was encouraging, the biocompatibility and in vivo bone response to these formulations are still unknown. Therefore, the present study aimed to evaluate the in vivo performance of BG supplemented CPC, either pure or supplemented with PLGA microparticles, via both ectopic and orthotopic implantation models in rats. Pre-set scaffolds in four different formulations (1: CPC; 2: CPC/BG; 3: CPC/PLGA; and 4: CPC/PLGA/BG) were implanted subcutaneously and into femoral condyle defects of rats for 2 and 6 weeks. Upon ectopic implantation, incorporation of BG into CPC improved the soft tissue response by improving capsule and interface quality. Additionally, the incorporation of BG into CPC and CPC/PLGA showed 1.8- and 4.7-fold higher degradation and 2.2- and 1.3-fold higher bone formation in a femoral condyle defect in rats compared to pure CPC and CPC/PLGA, respectively. Consequently, these results highlight the potential of BG to be used as an additive to CPC to improve the biological performance for bone regeneration applications. Nevertheless, further confirmation is necessary regarding long-term in vivo studies, which also have to be performed under compromised wound-healing conditions. (C) 2012 Acta Materialia Inc. Published by Elsevier B.V. All rights reserved.en
dc.description.sponsorshipSmart Mix Program of the Netherlands Ministry of Economic Affairs
dc.description.sponsorshipNetherlands Ministry of Education, Culture and Science
dc.publisherElsevier B.V.
dc.relation.ispartofActa Biomaterialia
dc.rightsAcesso restrito
dc.subjectBone substituteen
dc.subjectCalcium phosphate cementen
dc.subjectBioactive glassen
dc.subjectIn vivoen
dc.titleIncorporation of bioactive glass in calcium phosphate cement: An evaluationen
dc.contributor.institutionRadboud Univ Nijmegen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.description.affiliationRadboud Univ Nijmegen, Med Ctr, Dept Biomat 309, NL-6500 HB Nijmegen, Netherlands
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Mat Engn, BR-16015223 Sao Carlos, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.sourceWeb of Science

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