Short and long term impact of adenotonsillectomy on the immune system

Short and long term impact of adenotonsillectomy on the immune system

Alternative title Repercussão da adenotonsilectomia sobre o sistema imune a curto e longo prazo
Author Santos, Fabio Pires Autor UNIFESP Google Scholar
Weber, Raimar Google Scholar
Fortes, Bibiana Callegaro Google Scholar
Nagata Pignatari, Shirley Shizue Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Prof Edmundo Vasconcelos Hosp
Universidade de São Paulo (USP)
Prof Edmund Vasconcelos Hosp
Brazilian ENT HNS Assoc
Abstract Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.
Keywords adenoidectomy
child
immune system
Language English
Date 2013-01-01
Published in Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.
ISSN 1808-8694 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
Extent 28-34
Origin http://dx.doi.org/10.5935/1808-8694.20130006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315660800006
SciELO ID S1808-86942013000100006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/35760

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