Chronic Exercise Promotes Alterations in the Neuroendocrine Profile of Elderly People

Chronic Exercise Promotes Alterations in the Neuroendocrine Profile of Elderly People

Author Alves, Eduardo da Silva Autor UNIFESP Google Scholar
Souza, Helton de Sá Autor UNIFESP Google Scholar
Rosa, João Paulo Pereira Autor UNIFESP Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Pimentel, Gustavo Duarte Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Viana, Valter Antonio Rocha Autor UNIFESP Google Scholar
Boscolo, Rita Aurélia Autor UNIFESP Google Scholar
Grassmann, Viviane Autor UNIFESP Google Scholar
Santana, Marcos Gonçalves de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Ctr Estudo Psicobiol Exercicio
Universidade Federal de São Paulo (UNIFESP)
Univ Extremo Sul Catarinense
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de Goiás (UFG)
Abstract Aging and physical inactivity are 2 factors that favour the development of cardiovascular disease, metabolic syndrome, obesity, and diabetes. in contrast, adopting a habitual moderate exercise routine may be a nonpharmacological treatment alternative for neuroendocrine aging disorders. We aimed to assess the effects of moderate exercise training on the metabolic profiles of elderly people with sedentary lifestyles. Fourteen sedentary, healthy, elderly male volunteers participated in a moderate training regimen for 60 min/day, 3 days/week for 24 weeks at a work rate equivalent to their ventilatory aerobic threshold. the environment was maintained at a temperature of 23 +/- 2 degrees C, with a humidity of 60 +/- 5 %. Blood samples for analysis were collected at 3 intervals: at baseline (1 week before training began), and 3 and 6 months after training. the training promoted increased aerobic capacity (relative VO2, and time and velocity to VO(2)max; (p < 0.05)) and reduced serum alpha-MSH (p < 0.05) after 3 months of training when compared with the baseline data. in addition, serum thyroid hormone (T3 and T4) was reduced after 6 months of training compared with baseline levels. Our results demonstrate that a moderate exercise training protocol improves the metabolic profile of older people, and metabolic adaptation is dependent on time.
Keywords Aerobic capacity
Neuropeptides
Aging
Moderate training
Language English
Sponsor Associação Fundo de Incentivo à Pesquisa (AFIP)
Centro de Estudo em Psicobiologia do Exercício (CEPE)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Universidade Federal de São Paulo (UNIFESP)
Date 2012-12-01
Published in Hormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 44, n. 13, p. 975-979, 2012.
ISSN 0018-5043 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 975-979
Origin https://dx.doi.org/10.1055/s-0032-1316294
Access rights Closed access
Type Article
Web of Science ID WOS:000312501800008
URI https://repositorio.unifesp.br/handle/11600/35581

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