Behavioral changes and brain energy metabolism dysfunction in rats treated with methamphetamine or dextroamphetamine

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Feier, Gustavo
Valvassori, Samira S.
Lopes-Borges, Jessica
Varela, Roger B.
Bavaresco, Daniela V.
Scaini, Giselli
Morais, Meline O.
Andersen, Monica L. [UNIFESP]
Streck, Emilio L.
Quevedo, Joao
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Studies have demonstrated that AMPHs produce long-term damage to the brain dopaminergic, serotoninergic and glutamatergic regions. Prefrontal cortex, amygdala, hippocampus and striatum appear to be involved in the toxicity and behavioral changes induced by AMPHs. A single dose of AMPH causes mitochondrial dysfunction and oxidative stress in rat brain. the goal of the present study was thus to investigate the potency of two amphetamines, dextroamphetamine (d-AMPH) and methamphetamine (m-AMPH), on the behavior and energetic dysfunction in the brain of rats. d-AMPH and m-AMPH increased the crossing and rearing behaviors. the numbers of visits to the center were increased by d-AMPH and m-AMPH only at 2 mg/kg. Likewise, at a high dose (2 mg/kg), the injection of m-AMPH increased the amount of sniffing. the AMPHs significantly decreased the activities of Krebs cycle enzymes (citrate synthase and succinate dehydrogenase) and mitochondrial respiratory chain complexes (I-IV); nevertheless, this effect varied depending on the brain region evaluated. in summary, this study demonstrated that at high doses, m-AMPH, increased stereotyped (sniffing) behavior in rats, but d-AMPH did not. However, this study shows that d-AMPH and m-AMPH seem to have similar effects on the brains energetic metabolism. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Neuroscience Letters. Clare: Elsevier B.V., v. 530, n. 1, p. 75-79, 2012.