Histological evolution of hepatitis C virus infection after renal transplantation
Nenhuma Miniatura disponível
Data
2012-11-01
Autores
Oliveira Uehara, Silvia Naomi de [UNIFESP]
Emori, Christini Takemi [UNIFESP]
Pereira, Patrícia da Silva Fucuta [UNIFESP]
Perez, Renata M.
Medina Pestana, Jose Osmar
Lanzoni, Valeria Pereira
Souza e Silva, Ivonete Sandra [UNIFESP]
Benedito Silva, Antonio Eduardo [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background: information regarding histological progression of hepatitis C after renal transplant (RTx) is scarce. Aims: To analyze clinical and laboratory evolution and histological progression of hepatitis C in patients evaluated before and after RTx.Methods: Twenty-two HCV-infected patients submitted to liver biopsy pre- and post-RTx were included. A semiquantitative analysis of necroinflammatory activity and fibrosis staging was performed and the two biopsies were compared.Results: Patients were mostly men (73%) with mean age of 36 +/- 9 yr. Time post-transplant was 4 +/- 2 yr and time between biopsies was 5 +/- 2 yr. An elevation of alanine aminotransferase (p = 0.041) and aspartate aminotransferase (p = 0.004) levels was observed in the post-transplant period. Fibrosis progression after renal transplantation was observed in 11 (50%) of the patients, and necroinflammatory activity worsening was observed in 7 (32%) of the patients. the histological progression occurred even among those without significant histological lesions in pre-transplant biopsy.Conclusion: the findings of this study suggest that the practice of indicating treatment in the pre-transplant phase based mainly on histological disease should be revised, because a high proportion of patients present disease progression. Because interferon cannot be used safely after RTx, treatment should be indicated for all ESRD patients with hepatitis C.
Descrição
Citação
Clinical Transplantation. Hoboken: Wiley-Blackwell, v. 26, n. 6, p. 842-848, 2012.