Vitreoretinal interface in central serous choroidopathy: a retrospective case-control study

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Theocharis, Ioannis P.
Lima, Luiz H. [UNIFESP]
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Purpose: To investigate the frequency and patterns of vitreoretinal adherence in central serous choroidopathy (CSC) using spectral domain optical coherence tomography (SD-OCT) imaging and compare them with normal subject.Methods: A descriptive observational analytical retrospective casecontrol study. the study patients were split into non-chronic and chronic CSC groups and compared with an age- and gender-matched control group composed of healthy individuals without CSC. Five patterns of vitreoretinal adherence were defined: lacunae, partial posterior vitreous detachment (partial-PVD), epiretinal membrane (ERM), focal vitremacular adherence (VMA) and no recognizable pattern. Statistical analysis was performed.Results: One hundred and four eyes of 52 patients were included in this study. Forty-eight eyes of 24 patients had chronic CSC and 56 eyes of 28 patients had non-chronic CSC. the control group for chronic CSC included 96 normal eyes of 48 subjects, and the control group for non-chronic CSC included one hundred and twelve normal eyes of 56 subjects. We found a recognizable pattern of the vitreoretinal interface (lacuna, partial-PPV, VMA or ERM) more often in non-chronic CSC (p = 0.0001, OR = 6.51 and CI = 2.7115.62) and in chronic CSC patients (p = 0.001, OR = 4.05, CI: 1.779.57) than in normal subjects.Conclusion: the proportion of patterns of vitreoretinal adherence and interface found in CSC changes with age and manifests differently compared with normal eyes. the results indicate early changes in CSC patients younger than 40 years of old bilaterally.
Acta Ophthalmologica. Hoboken: Wiley-Blackwell, v. 90, n. 7, p. E505-E511, 2012.