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dc.contributor.authorPezato, Rogério [UNIFESP]
dc.contributor.authorSwierczynska-Krepa, M.
dc.contributor.authorNizankowska-Mogilnicka, E.
dc.contributor.authorDerycke, L.
dc.contributor.authorBachert, C.
dc.contributor.authorPerez-Novo, C. A.
dc.identifier.citationAllergy. Hoboken: Wiley-Blackwell, v. 67, n. 11, p. 1347-1356, 2012.
dc.description.abstractChronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.en
dc.description.sponsorshipFlemish Research Board (FWO Post-doctoral mandate)
dc.description.sponsorshipEuropean Union
dc.description.sponsorshipSão Paulo State Military Police-Health Department, Brazil
dc.description.sponsorshipFlemish Scientific Research Board FWO
dc.description.sponsorshipInteruniversity Attraction Poles Program
dc.rightsAcesso aberto
dc.subjectaspirin-exacerbated respiratory diseaseen
dc.subjectchronic rhinosinusitisen
dc.subjectnasal polyposisen
dc.subjectstaphylococcal enterotoxinsen
dc.titleRole of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitisen
dc.contributor.institutionUniv Ghent
dc.contributor.institutionJagiellonian Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, B-9000 Ghent, Belgium
dc.description.affiliationJagiellonian Univ, Sch Med, Dept Med, Krakow, Poland
dc.description.affiliationUniversidade Federal de São Paulo, Dept Otorhinolaryngol, São Paulo, Brazil
dc.description.affiliationMedex, Bielsko Biala, Poland
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Otorhinolaryngol, São Paulo, Brazil
dc.description.sponsorshipIDFlemish Research Board (FWO Post-doctoral mandate): FWO08-PDO-117
dc.description.sponsorshipIDEuropean Union: 17
dc.description.sponsorshipIDFlemish Scientific Research Board FWO: A12/5-HB-KH3
dc.description.sponsorshipIDFlemish Scientific Research Board FWO: G.0436.04
dc.description.sponsorshipIDInteruniversity Attraction Poles Program: IAP P6/35
dc.description.sourceWeb of Science

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