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dc.contributor.authorOmena, Cristhiane Maria Bazilio
dc.contributor.authorValentim, Iara Barros
dc.contributor.authorGuedes, Glaucevane da Silva
dc.contributor.authorRabelo, Luiza Antas
dc.contributor.authorMano, Camila Marinho
dc.contributor.authorEtelvino, José Henriques Bechara, [UNIFESP]
dc.contributor.authorSawaya, Alexandra Christine Helena Frankland
dc.contributor.authorTrevisan, Maria Teresa Salles
dc.contributor.authorCosta, Joao Gomes da
dc.contributor.authorFerreira, Roberta Costa Silva
dc.contributor.authorSant'Ana, Antonio Euzebio Goulart
dc.contributor.authorGoulart, Marilia Oliveira Fonseca
dc.date.accessioned2016-01-24T14:27:54Z
dc.date.available2016-01-24T14:27:54Z
dc.date.issued2012-11-01
dc.identifierhttp://dx.doi.org/10.1016/j.foodres.2012.07.010
dc.identifier.citationFood Research International. Amsterdam: Elsevier B.V., v. 49, n. 1, p. 334-344, 2012.
dc.identifier.issn0963-9969
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35420
dc.description.abstractEthanol extracts of powdered genipap (Genipa americana L), umbu (Spondia tuberosa A.) and siriguela (Spondia purpurea L) prepared from separate pulp, seeds and peel were investigated for their (i) antioxidant capacity, which was evaluated by various known methods; (ii) acetylcholinesterase (AChE) inhibitory activity; and (iii) cytotoxic effect on corneal epithelial cells of sheep. the highest values of total phenolic content were obtained with peel and seed extracts. Siriguela and umbu (seeds and peel) extracts displayed the highest antioxidant activities. Lipid peroxidation assays using mimetic biomembranes and mouse liver homogenates indicated that genipap pulp is a promising antioxidant. the investigation of phenols and organic acid contents revealed the presence of quercetin, citric and quinic acids, chlorogenic acid derivatives, among others, in several extracts, with the highest amount found in siriguela seeds. Genipap pulp and siriguela seed ethanol extracts presented an AChE inhibition zone similar to that of the positive control, carbachol. AChE inhibition assay with chlorogenic acid, one of the main constituents of siriguela seeds, revealed that this acid showed activity similar to that of the control physostigmine. These data suggest that these extracts are potentially important antioxidant supplements for the everyday human diet, pharmaceutical and cosmetic industries. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipINCT-Redoxoma
dc.description.sponsorshipINCT-Bioanalitica
dc.format.extent334-344
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Research International
dc.rightsAcesso aberto
dc.subjectTotal phenolic contenten
dc.subjectFree radical scavenging activityen
dc.subjectAntioxidant capacityen
dc.subjectBODIPYen
dc.subjectAcetylcholinesterase inhibitionen
dc.subjectTropical fruitsen
dc.titleAntioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits Antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruitsen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniv Fed Alagoas
dc.contributor.institutionUniv Pernambuco
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.description.affiliationUniv Fed Alagoas, Inst Quim & Biotecnol, BR-57072970 Maceio, AL, Brazil
dc.description.affiliationUniv Pernambuco, BR-56300000 Petrolina, PE, Brazil
dc.description.affiliationUniv Fed Alagoas, Rede Nordeste Biotecnol RENORBIO, BR-57072970 Maceio, AL, Brazil
dc.description.affiliationUniv Fed Alagoas, Inst Ciencias Biol & Saude, BR-57072970 Maceio, AL, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Bioquim, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biol Vegetal, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, CE, Brazil
dc.description.affiliationEmbrapa Tabuleiros Costeiros, Tabuleiro Martins, BR-57061970 Maceio, AL, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2008/58035-6
dc.identifier.fileWOS000311592500043.pdf
dc.identifier.doi10.1016/j.foodres.2012.07.010
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000311592500043


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