Efficient and eco-friendly synthesis of iodinated aromatic building blocks promoted by iodine and hydrogen peroxide in water: a mechanistic investigation by mass spectrometry
Gallo, Rafael D. C.
Ferreira, Irlon M.
Casagrande, Gleison A.
Oliveira-Silva, Diogo [UNIFESP]
Raminelli, Cristiano [UNIFESP]
Is part ofTetrahedron Letters
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The reaction of aromatic and heteroaromatic compounds with molecular iodine in the presence of aqueous hydrogen peroxide using water without any co-solvent at 50 degrees C for 24 h produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in very good yields. in addition, a mechanistic investigation for the iodination process was carried out by mass spectrometry. (C) 2012 Elsevier B.V. All rights reserved.
CitationTetrahedron Letters. Oxford: Pergamon-Elsevier B.V., v. 53, n. 40, p. 5372-5375, 2012.
Water as solvent
SponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
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