Study of Heparin in Intestinal Ischemia and Reperfusion in Rats: Morphologic and Functional Evaluation

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Ghadie, Majid Mohamad [UNIFESP]
Miranda-Ferreira, Regiane [UNIFESP]
Taha, Nabiha Saadi Abrahão [UNIFESP]
Maroso, A. S.
Moreti, R. J. Z.
Andraus, M. P.
Zempulski, P.
Monteiro, Hugo Pequeno [UNIFESP]
Simões, Manuel de Jesus [UNIFESP]
Fagundes, Djalma José [UNIFESP]
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To study whether treatment with heparin (HEP) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with HEP (100 U/kg intravenously) or saline solution (SS) before I (60 min), which was produced by occlusion of the superior mesenteric artery, and R (120 min). After I or I/R, we mounted 2-cm jejunal segment in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl, using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy. Compared with the sham group, jejunal contractions were similar in the I + HEP and the I/R + HEP groups, but reduced in the I + SS and the I/R + SS groups. the jejunal enteric nerves were damaged in the I + SS and the I/R + SS, but not in the I + HEP and the I/R + HEP cohorts. These results suggested that HEP attenuated intestinal dysfunction caused by I and I/R.
Transplantation Proceedings. New York: Elsevier B.V., v. 44, n. 8, p. 2300-2303, 2012.