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dc.contributor.authorLerner, Tatiana Goberstein
dc.contributor.authorMiranda, Michele da Costa
dc.contributor.authorLera, Andrea Thaumaturgo
dc.contributor.authorUeda, Aline [UNIFESP]
dc.contributor.authorBriones, Bruna
dc.contributor.authorDel Giglio, Auro
dc.contributor.authorRiechelmann, Rachel
dc.identifier.citationContemporary Clinical Trials. New York: Elsevier B.V., v. 33, n. 5, p. 1019-1022, 2012.
dc.description.abstractPurpose: To assess the frequency with which editorial authors report personal conflict of interest and investigate a possible association between the presence of such conflicts and favorable opinion.Methods: Eligible studies were editorials of phase III clinical trials of antitumor drugs or symptom management published from January 2007 to December 2009 in four top oncology journals. Data from the editorials were collected and each editorial opinion was classified as favorable, neutral or unfavorable with respect to the experimental therapy.Results: Fifty-four editorials were included: 23 (43%) reported at least one conflict of interest, with the most frequent one being consultancy fees. Conclusions of editorial authors were classified as favorable in 18 editorials (33%). Sensitivity analysis found an association between self-reported conflict of interest of the editorial author and editorial favorable opinion (RR:2.7; 95% Cl 1.2-6.1; p = 0.019).Discussion: Besides the high proportion of conflict of interest among editorial authors discussing phase Ill clinical trials, study interpretation may be influenced by their financial relationships with industry. (C) 2012 Elsevier Inc. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofContemporary Clinical Trials
dc.rightsAcesso restrito
dc.subjectConflict of interesten
dc.subjectAntineoplastic agents/pharmacologyen
dc.subjectClinical trials as topic/ethicsen
dc.subjectPeriodicals as topicen
dc.titleThe prevalence and influence of self-reported conflicts of interest by editorial authors of phase III cancer trialsen
dc.contributor.institutionInst Pele Saudavel
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationICESP, Dept Med Oncol, BR-01246000 São Paulo, Brazil
dc.description.affiliationFMABC, São Paulo, Brazil
dc.description.affiliationInst Pele Saudavel, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science

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