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dc.contributor.authorLoth, Eduardo Alexandre
dc.contributor.authorBiazin, Samia Khalil
dc.contributor.authorPaula, Claudete Rodrigues
dc.contributor.authorGarcia Simao, Rita de Cassia
dc.contributor.authorFranco, Marcello Fabiano de [UNIFESP]
dc.contributor.authorPuccia, Rosana [UNIFESP]
dc.contributor.authorGandra, Rinaldo Ferreira
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 174, n. 3, p. 187-191, 2012.
dc.description.abstractParacoccidioidomycosis (PCM), a disease caused by the fungus Paracoccidioides brasiliensis (Pb), is highly prevalent in Brazil, where it is the principal cause of death by systemic mycoses. the disease primarily affects men aged 30-50 year old and usually starts as a pulmonary focus and then may spread to other organs and systems, including the joints. the present study aimed to develop an experimental model of paracoccidioidomycotic arthritis. Two-month-old male Wistar rats (n = 48) were used, divided in 6 groups: test groups EG/15 and EG/45 (received one dose of 100 mu l of saline containing 10(5) Pb viable yeasts in the knee); heat killed Pb-group HK/15 and HK/45 (received a suspension of 10(5) Pb nonviable yeasts in the knee) and control groups CG/15 and CG/45 (received only sterile saline in the knee). the rats were killed 15 and 45 days postinoculation. in contrast with the control rats, the histopathology of the joints of rats of the test groups (EG/15 and EG/45) revealed a picture of well-established PCM arthritis characterized by extensive sclerosing granulomatous inflammation with numerous multiple budding fungal cells. the X-ray examination revealed joint alterations in these groups. Only metabolic active fungi evoked inflammation. the experimental model was able to induce fungal arthritis in the knees of the rats infected with metabolic active P. brasiliensis. the disease tended to be regressive and restrained by the immune system. No evidence of fungal dissemination to the lungs was observed.en
dc.description.sponsorshipFundacao Araucaria-Fundo Parana/SETI
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.rightsAcesso restrito
dc.subjectParacoccidioides brasiliensisen
dc.subjectVirulence factorsen
dc.titleExperimental Model of Arthritis Induced by Paracoccidioides brasiliensis in Ratsen
dc.contributor.institutionHosp Univ Oeste Parana
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Estadual Oeste Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationHosp Univ Oeste Parana, BR-85806470 Cascavel, PR, Brazil
dc.description.affiliationUniv São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Estadual Oeste Parana, Cascavel, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science

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