Role of chymase in diabetic nephropathy

Date
2012-08-01Author
Cristovam, Priscila C. [UNIFESP]
Carmona, Adriana K. [UNIFESP]
Arnoni, Carine P. [UNIFESP]
Maquigussa, Edgar [UNIFESP]
Pereira, Luciana G. [UNIFESP]
Boim, Mirian A. [UNIFESP]
Type
ArtigoISSN
1535-3702Is part of
Experimental Biology and MedicineDOI
10.1258/ebm.2012.011356Metadata
Show full item recordAbstract
Chymase is an alternative pathway for angiotensin-converting enzyme in angiotensin II (Ang II) formation, and its expression is increased in human diabetic kidneys and in human mesangial cells (MCs) stimulated with high glucose. in addition, chymase activates transforming growth factor (TGF-beta 1) via an Ang II-independent pathway. the aim of this study was to evaluate the role of chymase on TGF-beta 1 activation in diabetic rats and in rat MCs (RMCs) stimulated with high glucose (HG). Diabetes was induced in male Wistar rats by streptozotocin (60 mg/kg, intravenous). After 30 (D30) or 60 (D60) days, chymase activity and the expression of profibrotic markers were evaluated. RMCs were stimulated with HG in the presence or absence of 50 mu mol/L chymostatin, a chymase inhibitor, or 100 nmol/L of losartan, an Ang II antagonist. Chymase activity and expression increased in 060 kidneys, with increased expression of fibronectin, type I and III collagen, TGF-beta 1 and Smad 3 and with no change in Smad 7 expression. RMCs exposed to HG presented increases in chymase activity and expression, together with upregulation in fibrosis markers and in the TGF-beta 1 signaling pathway. All these effects were reversed by chymostatin and by losartan, but type 1 angiotensin II receptor blockade did not interfere with the Smad 3 and 7 pathway. Similar to HG-stimulated RMCs, control RMCs treated with chymase responded with increased expression of TGF-beta 1, Smad 3 and fibrosis markers. These effects were reversed by chymostatin but not by losartan. the results indicate an important role for chymase in inducing fibrosis through TGF-beta 1 activation, parallel with Ang II effects.
Citation
Experimental Biology and Medicine. London: Royal Soc Medicine Press Ltd, v. 237, n. 8, p. 985-992, 2012.Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao Oswaldo Ramos (FOR)
Fundo de Auxilio aos Docentes e Alunos (FADA)
Collections
- EPM - Artigos [17701]
Related items
Showing items related by title, author, creator and subject.
-
Encruzilhada. Artigos dos estudantes de arte contemporânea da Unifesp (2023)
Arantes, Pedro Fiori [UNIFESP]; Pires, Catarina Silva [UNIFESP]; Souza, Larissa Silva de [UNIFESP]; Miramontes, Luana [UNIFESP]; Jean, Marci [UNIFESP]; Alcarde, Yasmin Tainá Lana de [UNIFESP]; Lima, Ingrid Dos Santos [UNIFESP]; Costa, João Henrique Lopes da [UNIFESP]; Marques, Yago Maciel [UNIFESP]; Rocha, Romario Lopes [UNIFESP]; Gomes, Gustavo Bitencourt [UNIFESP]; Dias, Camila Oliveira [UNIFESP]; Santos, Thaynná Baltazar dos[UNIFESP]; Guedes, Beatriz [UNIFESP]; Melo, Gabriella [UNIFESP]; Francesquini, Maria Sueli de Camargo [UNIFESP]; Almeida, Raphael Gomes de [UNIFESP]; Morita, Yumi [UNIFESP]; Araújo, Isadora Trindade [UNIFESP]; Santo, Micaele Silva [UNIFESP]; Rocha, Karina Braga da [UNIFESP]; Campos, Maria Eduarda [UNIFESP]; Soares, Juliane Pereira [UNIFESP]; Silva, Gabrielly A. Santiago da [UNIFESP]; Lima, Gabrielle Pereira [UNIFESP]; Marzola, Ana Paula [UNIFESP]; Mões, Gustavo [UNIFESP]; Campos, Hellen [UNIFESP]; Baba, Luccas Ryoichi Kimura [UNIFESP]; Reis, Mariana [UNIFESP]; França, Milena [UNIFESP]; Yamaguchi, Ângela Harumi [UNIFESP]; Marassi, Beatriz [UNIFESP]; Porfirio, Beatriz [UNIFESP]; Mayumi, Cristiane [UNIFESP]; Agbanusi, Gladys Uju Balbino [UNIFESP]; Calixto, Fernanda [UNIFESP]; Capelli, Thalles [UNIFESP] (Universidade Federal de São Paulo, 2023)A arte contemporânea é, acima de tudo, multidisciplinar. A experimentação e a quebra de limites são primordiais para a existência desse campo tão vibrante e diversificado que permite que os artistas se expressem de forma ...
-
I Diretriz brasileira de cardio-oncologia pediátrica da Sociedade Brasileira de Cardiologia
Seber, Adriana [UNIFESP]; Miachon, Adriana Siviero [UNIFESP]; Tanaka, Ana Cristina Sayuri; Spinola-Castro, Angela Maria [UNIFESP]; Carvalho, Antonio Carlos [UNIFESP]; Petrilli, Antonio Sergio [UNIFESP]; Macedo, Carla Renata Pacheco Donato [UNIFESP]; Nars, Clarissa Carvalho Fongaro [UNIFESP]; Terzian, Claudia Naufel [UNIFESP]; Castro Junior, Claudio Galvão de; Santos, Cleusa Cavalcanti Lapa; Guerra, Cristina Chaves dos Santos; Silva, Dafne Cardoso Bourguignon da [UNIFESP]; Bassi, Débora Ugayama; Azeka, Estela; Feitosa, Fabiana Aragão; Hamamoto, Fernando [UNIFESP]; Szarf, Gilberto [UNIFESP]; Lederman, Henrique Manoel [UNIFESP]; Rigon Junior, Humberto João; Jatene, Ieda Biscegli; Mota, Isabele Coelho Fonseca da; Perrud, Jeferson Adriano [UNIFESP]; Soares Junior, José; Gutierrez, Julián Arango; Perin, Juliana Pepe Marinho [UNIFESP]; Soares, Juliana dos Santos [UNIFESP]; Catani, Liane Hulle; Tsai, Liliana Yu [UNIFESP]; Vianna, Livia Cristina [UNIFESP]; Paiva, Marcelo Goulart; Santos, Marcelo José; Ishigai, Marcia Marcelino de Souza [UNIFESP]; Diógenes, Maria Suely Bezerra [UNIFESP]; Alves, Maria Teresa de Seixas [UNIFESP]; Piedade, Maria Tereza Castro [UNIFESP]; Parreiras, Mariana; Cypriano, Mônica [UNIFESP]; Negrini, Nilce da Silva [UNIFESP]; Campos Filho, Orlando [UNIFESP]; Figueiredo, Paula Andrade [UNIFESP]; Novaes, Paulo Eduardo [UNIFESP]; Camargo, Paulo Roberto [UNIFESP]; Maia, Priscila dos Santos [UNIFESP]; Petrilli, Renata [UNIFESP]; Arduini, Rodrigo Genaro [UNIFESP]; Gouveia, Roseane Vasconcelos [UNIFESP]; Teruya, Suzana Barbosa Miranda [UNIFESP]; Moisés, Valdir Ambrósio [UNIFESP]; Morais, Vera Lúcia Lins de (Sociedade Brasileira de Cardiologia - SBC, 2013-05-01) -
Guerras culturais em verde e amarelo
Arantes, Pedro Fiori [UNIFESP]; Okuma, André [UNIFESP]; Nascimento, Giulia dos Santos [UNIFESP]; Melo, Keyla Vasconcelos de [UNIFESP]; Lorena, Diego [UNIFESP]; Alves, Amanda [UNIFESP]; Brait, Ana Laura [UNIFESP]; Alves, Gustavo Almeida [UNIFESP]; Fernandes, Cristina Naiara [UNIFESP]; Avelino, Larissa [UNIFESP]; Paloma, Oliveira [UNIFESP]; Bertellotti, André Zaparoli [UNIFESP]; Carreño, Rebeca Nieves Inostroza [UNIFESP]; Feo, Amanda [UNIFESP]; Andrade, Bruna [UNIFESP]; Garotti, Josiane [UNIFESP]; Flauto, Larissa [UNIFESP]; Tavares, Melissa [UNIFESP]; Barbosa, Ana Beatriz Tavares [UNIFESP]; Alejarra, Melissa Maria dos Santos [UNIFESP]; Santos, Nicole Pinheiro [UNIFESP]; Dourado, Kamilla [UNIFESP]; Silva, Pamela [UNIFESP]; Goyano, Lucius [UNIFESP]; Meneses, Maria Luiza [UNIFESP]; Ferreira, Gabriela [UNIFESP]; Monteiro, Paloma [UNIFESP]; Oliveira, Marcelo Lauton de [UNIFESP]; Paula, Patrícia Pinheiro Antunes de [UNIFESP]; Santos, Isabella Mendes dos [UNIFESP]; Borges, Júlia Rodrigues [UNIFESP] (Universidade Federal de São Paulo, 2022)Queridos/as leitores/as, bem-vindos/as ao nosso campo de batalha – e de estudos. Vocês estão prestes a ler um livro perigoso. Ele fala sobre muito do que estamos vivendo no Brasil dos últimos anos, olhando esse nosso ...