Accuracy of Preoperative Biopsies Compared With Surgical Specimens in the Diagnosis of Colorectal Adenocarcinoma

Accuracy of Preoperative Biopsies Compared With Surgical Specimens in the Diagnosis of Colorectal Adenocarcinoma

Author Luderer, Loreley A. Autor UNIFESP Google Scholar
Lustosa, Suzana A. S. Autor UNIFESP Google Scholar
Neto, Ricardo Artigiani Autor UNIFESP Google Scholar
Lopes, Filipe T. Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Municipal Dr Munir Rafful
Univ Ctr Volta Redonda
Abstract Objective. Since the first data from a patient with colorectal adenocarcinoma are obtained by biopsy, this study evaluated the accuracy of diagnosis by biopsy as compared with the diagnostic potential of the surgical specimen, considering the histological type, grade of differentiation, and immunohistochemical expression of p53. Methods. the specimens were obtained from 80 patients assisted at Hospital São Paulo. the biopsy and surgical specimen sections were stained by hematoxylin-eosin and immunohistochemistry and compared by 3 pathologists blinded to the evaluations. Results. the accuracy for the histological types was 88%. the grade of differentiation presented an accuracy of 70% with Kappa = .48. the expression of protein p53 exhibited an accuracy of 68% with Kappa = .22. Conclusion. the preoperative biopsy of colorectal adenocarcinoma presented good accuracy compared with histopathological examination of the surgical specimen, but with weak to moderate effective degree of agreement between the results.
Keywords colorectal adenocarcinoma
colorectal biopsy
surgical specimen
accuracy
colorectal carcinoma
Language English
Date 2012-08-01
Published in International Journal of Surgical Pathology. Thousand Oaks: Sage Publications Inc, v. 20, n. 4, p. 355-359, 2012.
ISSN 1066-8969 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 355-359
Origin http://dx.doi.org/10.1177/1066896912437412
Access rights Closed access
Type Article
Web of Science ID WOS:000306428800004
URI http://repositorio.unifesp.br/handle/11600/35158

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