Short sleep duration and obesity: mechanisms and future perspectives

Short sleep duration and obesity: mechanisms and future perspectives

Author Zimberg, Iona Zalcman Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Del Re, Mariana Pantaleão Autor UNIFESP Google Scholar
Carneiro, Aline Millani Google Scholar
Souza, Helton de Sá Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Extremo Catarinense
Abstract A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory-based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in the metabolic and endocrine alterations, including decreased glucose tolerance and insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure. Altogether, evidences point to a possible role of decreased sleep duration in the current epidemic of obesity and therefore present literature highlights the importance of getting enough good sleep for metabolic health. Many aspects still need to be clarified and intervention studies also need to be conducted. Copyright (c) 2012 John Wiley & Sons, Ltd.
Keywords Sleep
Language English
Sponsor Associação Fundo de Incentivo Pesquisa (AFIP)
Centro de Estudos em Psicobiologia e Exercício (CEPE)
Centro de Estudo Multidisciplinar em Sonolência e Acidentes (CEMSA)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 1998/14303-3
FAPESP: 2009/05657-2
FAPESP: 2008/09565-2
FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
Date 2012-08-01
Published in Cell Biochemistry and Function. Hoboken: Wiley-Blackwell, v. 30, n. 6, p. 524-529, 2012.
ISSN 0263-6484 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 524-529
Access rights Closed access
Type Review
Web of Science ID WOS:000307787200013

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