Acute restraint differently alters defensive responses and fos immunoreactivity in the rat brain

Show simple item record

dc.contributor.author Andrade, José Simões de [UNIFESP]
dc.contributor.author Abrão, Renata Oliveira [UNIFESP]
dc.contributor.author Céspedes, Isabel Cristina [UNIFESP]
dc.contributor.author Garcia, Marcia Carvalho [UNIFESP]
dc.contributor.author Nascimento, Juliana Olivetti Guzman [UNIFESP]
dc.contributor.author Spadari-Bratfisch, Regina Celia [UNIFESP]
dc.contributor.author Melo-Thomas, Liana [UNIFESP]
dc.contributor.author Silva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.author Viana, Milena de Barros [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:22Z
dc.date.available 2016-01-24T14:27:22Z
dc.date.issued 2012-06-15
dc.identifier https://dx.doi.org/10.1016/j.bbr.2012.03.034
dc.identifier.citation Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 232, n. 1, p. 20-29, 2012.
dc.identifier.issn 0166-4328
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/34996
dc.description.abstract Results from a previous study show that rats exposed to acute restraint display anxiogenic-like behavior, evidenced by facilitation of avoidance responses in the elevated T-maze (ETM) model of anxiety. in contrast, escape responses were unaltered by stress exposure. Since ETM avoidance and escape tasks seem to activate distinct sets of brain structures, it is possible that the differences observed with acute restraint are due to particularities in the neurobiological mechanisms which modulate these responses. in the present study, analysis of fos protein immunoreactivity (fos-ir) was used to map areas activated by exposure of male Wistar rats to restraint stress (30 min) previously (30 min) to the ETM. Corticosterone levels were also measured in stressed and non-stressed animals. Confirming previous observations restraint facilitated avoidance performance, an anxiogenic result, while leaving escape unaltered. Performance of the avoidance task increased fos-ir in the frontal cortex, intermediate lateral septum, basolateral amygdala, basomedial amygdala, lateral amygdala, anterior hypothalamus and dorsal raphe nucleus. in contrast, performance of escape increased fos-ir in the ventromedial hypothalamus, dorsolateral periaqueductal gray and locus ceruleus. Both behavioral tasks also increased fos-ir in the dorsomedial hypothalamus. Restraint significantly raised corticosterone levels. Additionally after restraint, fos-ir was predominantly seen in the basolateral amygdala and dorsal raphe of animals submitted to the avoidance task. This data confirms that different sets of brain structures are activated by ETM avoidance and escape tasks and suggests that acute restraint differently alters ETM behavior and the pattern of fos activation in the brain. (C) 2012 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 20-29
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Behavioural Brain Research
dc.rights Acesso restrito
dc.subject Stress en
dc.subject Restraint en
dc.subject Anxiety en
dc.subject Panic en
dc.subject Corticosterone en
dc.subject fos immunoreactivity en
dc.title Acute restraint differently alters defensive responses and fos immunoreactivity in the rat brain en
dc.type Artigo
dc.rights.license https://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Psychiat, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2011/17471-0
dc.identifier.doi 10.1016/j.bbr.2012.03.034
dc.description.source Web of Science
dc.identifier.wos WOS:000305595600004



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account