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dc.contributor.authorBassi, Enio Jose
dc.contributor.authorAlmeida, Danilo Candido de [UNIFESP]
dc.contributor.authorMendes Moraes-Vieira, Pedro Manoel
dc.contributor.authorSaraiva Camara, Niels Olsen
dc.identifier.citationStem Cell Reviews and Reports. Totowa: Humana Press Inc, v. 8, n. 2, p. 329-342, 2012.
dc.description.abstractMesenchymal stem cells (MSCs) are characterized as multipotent stromal cells with the capacity for both self-renewal and differentiation into mesodermal cell lineages. MSCs also have a fibroblast-like phenotype and can be isolated from several tissues. in recent years, researchers have found that MSCs secrete several soluble factors that exert immunosuppressive effects by modulating both innate (macrophages, dendritic and NK cells) and adaptive (B cells and CD4+ and CD8+ T cells) immune responses. This review summarizes the principal trophic factors that are related to immune regulation and secreted by MSCs under both autoimmune and inflammatory conditions. the understanding of mechanisms that regulate immunity in MSCs field is important for their future use as a novel cellular-based immunotherapy with clinical applications in several diseases.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipComplex Fluids INCT
dc.publisherHumana Press Inc
dc.relation.ispartofStem Cell Reviews and Reports
dc.rightsAcesso restrito
dc.subjectMesenchymal stem cellsen
dc.subjectImmune regulationen
dc.subjectImmune systemen
dc.subjectSoluble factorsen
dc.titleExploring the Role of Soluble Factors Associated with Immune Regulatory Properties of Mesenchymal Stem Cellsen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04039000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04039000 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 08/55447-1
dc.description.sponsorshipIDFAPESP: 09/51649-1
dc.description.sponsorshipIDFAPESP: 10/12295-7
dc.description.sponsorshipIDFAPESP: 10/16213-5
dc.description.sponsorshipIDFAPESP: 07/07139-3
dc.description.sponsorshipIDCNPq: 470533/2007-2
dc.description.sourceWeb of Science

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