Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

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2012-06-01
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Mantovani, N. P. [UNIFESP]
Azevedo, R. G. [UNIFESP]
Rabelato, J. T.
Sanabani, S.
Diaz, R. S. [UNIFESP]
Komninakis, S. V. [UNIFESP]
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We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.
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Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 50, n. 6, p. 2122-2125, 2012.
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