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dc.contributor.authorSiberry, George K.
dc.contributor.authorHarris, D. Robert
dc.contributor.authorOliveira, Ricardo Hugo
dc.contributor.authorKrauss, Margot R.
dc.contributor.authorHofer, Cristina B.
dc.contributor.authorTiraboschi, Adriana Aparecida
dc.contributor.authorMarques, Heloisa
dc.contributor.authorSucci, Regina C. [UNIFESP]
dc.contributor.authorAbreu, Thalita
dc.contributor.authorDella Negra, Marinella
dc.contributor.authorMofenson, Lynne M.
dc.contributor.authorHazra, Rohan
dc.contributor.authorNISDI PLACES Protocol
dc.identifier.citationJaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 60, n. 2, p. 214-218, 2012.
dc.description.abstractBackground: This study evaluated a wide range of viral load (VL) thresholds to identify a cut-point that best predicts new clinical events in children on stable highly active antiretroviral therapy (HAART).Methods: Cox proportional hazards modeling was used to assess the adjusted risk for World Health Organization stage 3 or 4 clinical events (WHO events) as a function of time-varying CD4, VL, and hemoglobin values in a cohort study of Latin American children on HAART >= 6 months. Models were fit using different VL cut-points between 400 and 50,000 copies per milliliter, with model fit evaluated on the basis of the minimum Akaike information criterion value, a standard model fit statistic.Results: Models were based on 67 subjects with WHO events out of 550 subjects on study. the VL cut-points of >2600 and >32,000 copies per milliliter corresponded to the lowest Akaike information criterion values and were associated with the highest hazard ratios (2.0, P = 0.015; and 2.1, P = 0.0058, respectively) for WHO events.Conclusions: in HIV-infected Latin American children on stable HAART, 2 distinct VL thresholds (>2600 and >32,000 copies/mL) were identified for predicting children at significantly increased risk for HIV-related clinical illness, after accounting for CD4 level, hemoglobin level, and other significant factors.en
dc.description.sponsorshipNational Institute of Child Health and Human Development (NICHD)
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJaids-Journal of Acquired Immune Deficiency Syndromes
dc.rightsAcesso aberto
dc.subjectpediatric HIV infectionen
dc.subjectviral load monitoringen
dc.subjectviral load thresholden
dc.subjectLatin Americaen
dc.titleEvaluation of Viral Load Thresholds for Predicting New World Health Organization Stage 3 and 4 Events in HIV-Infected Children Receiving Highly Active Antiretroviral Therapyen
dc.contributor.institutionEunice Kennedy Shriver Natl Inst Child Hlth & Hum
dc.contributor.institutionWestat Corp
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Infectol Emilio Ribas
dc.description.affiliationEunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS Brach, NIH, Bethesda, MD 20892 USA
dc.description.affiliationWestat Corp, Rockville, MD USA
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Puericultura & Pediat Martagao Gesteira, Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med São Paulo, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationInst Infectol Emilio Ribas, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sponsorshipIDNational Institute of Child Health and Human Development (NICHD): N01-HD-3-3345
dc.description.sponsorshipIDNational Institute of Child Health and Human Development (NICHD): HHSN267200800001C
dc.description.sponsorshipIDNational Institute of Child Health and Human Development (NICHD): N01-HD-8-0001
dc.description.sourceWeb of Science

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