Role of estrogen receptor alpha on vaginal epithelialization of patients with Mayer-Rokitansky-Kuster-Hauser syndrome submitted to neovaginoplasty using oxidized regenerated cellulose
Nenhuma Miniatura disponível
Data
2012-04-01
Autores
Kajikawa, Marcio Masashi
Katalin Jarmy-Di Bella, Zsuzsanna Ilona [UNIFESP]
Azevedo Focchi, Gustavo Rubino de [UNIFESP]
Dornelas, Juliane [UNIFESP]
Batista Castello Girao, Manoel Joao [UNIFESP]
Ferreira Sartori, Marair Gracio [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Introduction and hypothesis the purpose of this study was to evaluate the expression of estrogen receptor alpha (ER alpha) on the neovaginal tissue of patients with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome submitted to modified Abbe-McIndoe neovaginoplasty using oxidized regenerated cellulose.Methods the current study involved eight subjects with MRKH syndrome. Serial samples of the neovagina were obtained after the surgery and immunohistochemical detection of ER alpha was performed using antibody NCL-L-ER-6F11.Results the operation was performed successfully in all subjects without complications. A total of 22 samples of neovaginal tissue were analyzed. the expression of ER alpha was detected only 6 months after the surgery, when the neovagina acquired characteristics of normal vagina.Conclusion in our study, the expression of ER alpha occurred when complete epithelialization of vaginal tissue was ob-served. Other mechanisms may be involved in the formation of vaginal epithelium in patients with MRKH syndrome.
Descrição
Citação
International Urogynecology Journal. London: Springer London Ltd, v. 23, n. 4, p. 467-472, 2012.