Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

Author Pimentel, Gustavo Duarte Autor UNIFESP Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa, Jose Cesar Autor UNIFESP Google Scholar
Oliveira, Juliana Lopez de Autor UNIFESP Google Scholar
Hachul, Ana Claudia Losinskas Autor UNIFESP Google Scholar
Souza, Gabriel Inacio Honorato de Autor UNIFESP Google Scholar
Carmo, Maria das Gracas Tavares do Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Seelaender, Marilia Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Watanabe, Regina Lucia Harumi Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet the offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. the blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-alpha and IL1-beta, concentrations (P<.05). TLR4, NF kappa Bp65 and MyD88 were higher (P <.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. in other words, the effect remains after the consumption of the standard chow by offspring. (C) 2012 Elsevier Inc. All rights reserved.
Keywords Trans fatty acids
Hypothalamic inflammation
Cytokines
Adiponectin receptor
Fetal programming
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-03-01
Published in Journal of Nutritional Biochemistry. New York: Elsevier B.V., v. 23, n. 3, p. 265-271, 2012.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 265-271
Origin http://dx.doi.org/10.1016/j.jnutbio.2010.12.003
Access rights Closed access
Type Article
Web of Science ID WOS:000300914200008
URI http://repositorio.unifesp.br/handle/11600/34681

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