Paradoxical sleep deprivation induces muscle atrophy

Paradoxical sleep deprivation induces muscle atrophy

Author Dattilo, Murilo Autor UNIFESP Google Scholar
Antunes, Hanna Karen Moreira Autor UNIFESP Google Scholar
Medeiros, Alessandra Autor UNIFESP Google Scholar
Mônico-Neto, Marcos Autor UNIFESP Google Scholar
Souza, Helton de Sá Google Scholar
Lee, Kil Sun Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
CEPE
Abstract Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleepdeprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. the 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012
Keywords cross-sectional area
corticosterone
muscle atrophy
paradoxical sleep deprivation
testosterone
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Federal de São Paulo (UNIFESP)
Fundo de Auxllio aos Docentes e Alunos (FADA)
Grant number FAPESP: 2009/11056-1
FAPESP: 98/14303-3
Date 2012-03-01
Published in Muscle & Nerve. Malden: Wiley-Blackwell, v. 45, n. 3, p. 431-433, 2012.
ISSN 0148-639X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 431-433
Origin http://dx.doi.org/10.1002/mus.22322
Access rights Closed access
Type Article
Web of Science ID WOS:000300684600017
URI http://repositorio.unifesp.br/handle/11600/34656

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