Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy
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2012-03-01
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Almeida, Sandro Soares [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Guimarães, Paola Bianchi [UNIFESP]
Wasinski, Frederick [UNIFESP]
Pereira, Flavia Enira Gomes [UNIFESP]
Canzian, Mauro [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
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We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012
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Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.