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Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

dc.contributor.authorAlmeida, S. S. [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorGuimarães, Paola Bianchi [UNIFESP]
dc.contributor.authorWasinski, F. [UNIFESP]
dc.contributor.authorPereira, F. E. G. [UNIFESP]
dc.contributor.authorCanzian, Mauro [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorCarmona, Adriana Karaoglanovic [UNIFESP]
dc.contributor.authorVieira, Renata de Freitas Fisher [UNIFESP]
dc.contributor.authorNakaie, Clovis Ryuichi [UNIFESP]
dc.contributor.authorSabatini, R. A. [UNIFESP]
dc.contributor.authorPerosa, S. R. [UNIFESP]
dc.contributor.authorBacurau, Reury Frank Pereira
dc.contributor.authorGouveia, Telma Luciana Furtado [UNIFESP]
dc.contributor.authorGallo, Gloria [UNIFESP]
dc.contributor.authorWuertele, M. [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorSilva, J. A.
dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.authorAraujo, R. C. [UNIFESP]
dc.date.accessioned2016-01-24T14:17:56Z
dc.date.available2016-01-24T14:17:56Z
dc.date.issued2012-03-01
dc.identifierhttp://dx.doi.org/10.1038/tp.2012.21
dc.identifier.citationTranslational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.
dc.identifier.issn2158-3188
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34639
dc.description.abstractWe find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012en
dc.description.sponsorshipINNT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent5
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofTranslational Psychiatry
dc.rightsAcesso aberto
dc.subjectangiotensin I-converting enzymeen
dc.subjectcarbamazepineen
dc.subjectepilepsyen
dc.subjectTLEen
dc.titleCarbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsyen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNove de Julho Univ UNINOVE
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, BR-04023032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Arts Sci & Humanities, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, Brazil
dc.description.affiliationNove de Julho Univ UNINOVE, Dept Rehabil Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, Brazil
dc.identifier.fileWOS000315990800009.pdf
dc.identifier.doi10.1038/tp.2012.21
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000315990800009


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