Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

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Fecha
2012-03-01
Autor
Almeida, S. S. [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Guimarães, Paola Bianchi [UNIFESP]
Wasinski, F. [UNIFESP]
Pereira, F. E. G. [UNIFESP]
Canzian, Mauro [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Vieira, Renata de Freitas Fisher [UNIFESP]
Nakaie, Clovis Ryuichi [UNIFESP]
Sabatini, R. A. [UNIFESP]
Perosa, S. R. [UNIFESP]
Bacurau, Reury Frank Pereira
Gouveia, Telma Luciana Furtado [UNIFESP]
Gallo, Gloria [UNIFESP]
Wuertele, M. [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
Silva, J. A.
Pesquero, João Bosco [UNIFESP]
Araujo, R. C. [UNIFESP]
Tipo
Artigo
ISSN
2158-3188
Es parte de
Translational Psychiatry
DOI
10.1038/tp.2012.21
Metadatos
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Resumen
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012
Cita
Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.
Palabras clave
angiotensin I-converting enzyme
carbamazepine
epilepsy
TLE
Responsável
INNT
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
URI
http://repositorio.unifesp.br/handle/11600/34639
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