Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms

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dc.contributor.author Cassilhas, Ricardo Cardoso [UNIFESP]
dc.contributor.author Lee, Kil Sun [UNIFESP]
dc.contributor.author Fernandes, Jansen [UNIFESP]
dc.contributor.author Oliveira, Maria Gabriela Menezes de [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Meeusen, R.
dc.contributor.author Mello, Marco Tulio de [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:49Z
dc.date.available 2016-01-24T14:17:49Z
dc.date.issued 2012-01-27
dc.identifier https://dx.doi.org/10.1016/j.neuroscience.2011.11.029
dc.identifier.citation Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 202, p. 309-317, 2012.
dc.identifier.issn 0306-4522
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/34539
dc.description.abstract A growing body of scientific evidence indicates that exercise has a positive impact on human health, including neurological health. Aerobic exercise, which is supposed to enhance cardiovascular functions and metabolism, also induces neurotrophic factors that affect hippocampal neurons, thereby improving spatial learning and memory. Alternatively, little is known about the effect of resistance exercise on hippocampus-dependent memory, although this type of exercise is increasingly recommended to improve muscle strength and bone density and to prevent age-related disabilities. Therefore, we evaluated the effects of resistance training on spatial memory and the signaling pathways of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1), comparing these effects with those of aerobic exercise. Adult male Wistar rats underwent 8 weeks of aerobic training on a treadmill (AERO group) or resistance training on a vertical ladder (RES group). Control and sham groups were also included. After the training period, both AERO and RES groups showed improved learning and spatial memory in a similar manner. However, both groups presented distinct signaling pathways. Although the AERO group showed increased level of IGF-1, BDNF, TrkB, and g-CaMKII (calcium/calmodulin-dependent kinase II) in the hippocampus, the RES group showed an induction of peripheral and hippocampal IGF-1 with concomitant activation of receptor for IGF-1 (IGF-1R) and AKT in the hippocampus. These distinct pathways culminated in an increase of synapsin 1 and synaptophysin expression in both groups. These findings demonstrated that both aerobic and resistance exercise can employ divergent molecular mechanisms but achieve similar results on learning and spatial memory. (C) 2011 IBRO. Published by Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Research Incentive Fund Association (AFIP)
dc.description.sponsorship Psychobiology and Exercise Research Center (CEPE)
dc.description.sponsorship Multidisciplinary Center for the Study of Drowsiness and Accidents (CEMSA)
dc.description.sponsorship Research Innovation and Dissemination Centers-SLEEP (CEPID-Sleep)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 309-317
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuroscience
dc.rights Acesso restrito
dc.subject Spatial learning en
dc.subject Memory en
dc.subject Hippocampus en
dc.subject Physical exercise en
dc.subject Water maze en
dc.title Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution CEPE
dc.contributor.institution Vrije Univ Brussel
dc.description.affiliation UNIFESP Universidade Federal de São Paulo, Dept Psychobiol, CEPE Psychobiol & Exercise Res Ctr, BR-04020050 São Paulo, Brazil
dc.description.affiliation CEPE, Psychobiol & Exercise Res Ctr, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurophysiol, UNIFESP, São Paulo, Brazil
dc.description.affiliation Vrije Univ Brussel, Dept Human Physiol & Sports Med, Brussels, Belgium
dc.description.affiliationUnifesp UNIFESP Universidade Federal de São Paulo, Dept Psychobiol, CEPE Psychobiol & Exercise Res Ctr, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurophysiol, UNIFESP, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2008/03083-6
dc.identifier.doi 10.1016/j.neuroscience.2011.11.029
dc.description.source Web of Science
dc.identifier.wos WOS:000299908000029



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